Cox AD - Search Results

1

Geranylgeranyltransferase I as a target for anti-cancer drugs.

Philips MR, Cox AD. Philips MR, et al. Among authors: cox ad. J Clin Invest. 2007 May;117(5):1223-5. doi: 10.1172/JCI32108. J Clin Invest. 2007. PMID: 17476354 Free PMC article. Review.

2

Ras signalling on the endoplasmic reticulum and the Golgi.

Chiu VK, Bivona T, Hach A, Sajous JB, Silletti J, Wiener H, Johnson RL 2nd, Cox AD, Philips MR. Chiu VK, et al. Among authors: cox ad. Nat Cell Biol. 2002 May;4(5):343-50. doi: 10.1038/ncb783. Nat Cell Biol. 2002. PMID: 11988737

3

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.

Bivona TG, Pérez De Castro I, Ahearn IM, Grana TM, Chiu VK, Lockyer PJ, Cullen PJ, Pellicer A, Cox AD, Philips MR. Bivona TG, et al. Among authors: cox ad. Nature. 2003 Aug 7;424(6949):694-8. doi: 10.1038/nature01806. Epub 2003 Jun 29. Nature. 2003. PMID: 12845332

4

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

Bivona TG, Quatela SE, Bodemann BO, Ahearn IM, Soskis MJ, Mor A, Miura J, Wiener HH, Wright L, Saba SG, Yim D, Fein A, Pérez de Castro I, Li C, Thompson CB, Cox AD, Philips MR. Bivona TG, et al. Among authors: cox ad. Mol Cell. 2006 Feb 17;21(4):481-93. doi: 10.1016/j.molcel.2006.01.012. Mol Cell. 2006. PMID: 16483930 Free article.

5

Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.

Madigan JP, Bodemann BO, Brady DC, Dewar BJ, Keller PJ, Leitges M, Philips MR, Ridley AJ, Der CJ, Cox AD. Madigan JP, et al. Among authors: cox ad. Biochem J. 2009 Oct 23;424(1):153-61. doi: 10.1042/BJ20082377. Biochem J. 2009. PMID: 19723022 Free PMC article.

6

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif.

Tsai FD, Lopes MS, Zhou M, Court H, Ponce O, Fiordalisi JJ, Gierut JJ, Cox AD, Haigis KM, Philips MR. Tsai FD, et al. Among authors: cox ad. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):779-84. doi: 10.1073/pnas.1412811112. Epub 2015 Jan 5. Proc Natl Acad Sci U S A. 2015. PMID: 25561545 Free PMC article.

7

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

Cox AD, Der CJ, Philips MR. Cox AD, et al. Clin Cancer Res. 2015 Apr 15;21(8):1819-27. doi: 10.1158/1078-0432.CCR-14-3214. Clin Cancer Res. 2015. PMID: 25878363 Free PMC article. Review.

8

Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies.

Waters AM, Ozkan-Dagliyan I, Vaseva AV, Fer N, Strathern LA, Hobbs GA, Tessier-Cloutier B, Gillette WK, Bagni R, Whiteley GR, Hartley JL, McCormick F, Cox AD, Houghton PJ, Huntsman DG, Philips MR, Der CJ. Waters AM, et al. Among authors: cox ad. Sci Signal. 2017 Sep 26;10(498):eaao3332. doi: 10.1126/scisignal.aao3332. Sci Signal. 2017. PMID: 28951536 Free PMC article.

9

Farnesyltransferase inhibitors: potential role in the treatment of cancer.

Cox AD. Cox AD. Drugs. 2001;61(6):723-32. doi: 10.2165/00003495-200161060-00002. Drugs. 2001. PMID: 11398905 Review.

10

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.

Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM. Falsetti SC, et al. Among authors: cox ad. Mol Cell Biol. 2007 Nov;27(22):8003-14. doi: 10.1128/MCB.00057-07. Epub 2007 Sep 17. Mol Cell Biol. 2007. PMID: 17875936 Free PMC article.

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