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Highly potent growth hormone secretagogues.
Lu Z, Tata JR, Cheng K, Wei L, Chan WW, Butler B, Schleim KD, Jacks TM, Hickey G, Patchett AA. Lu Z, et al. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3657-9. doi: 10.1016/j.bmcl.2007.04.050. Epub 2007 Apr 25. Bioorg Med Chem Lett. 2007. PMID: 17482461
During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active in vitro than the best compound in the series we revealed before [Tata, J. R.; Lu, Z.; Jacks, T. M.; Schle …
During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was …
A combinatorial library of indinavir analogues and its in vitro and in vivo studies.
Cheng Y, Rano TA, Huening TT, Zhang F, Lu Z, Schleif WA, Gabryelski L, Olsen DB, Stahlhut M, Kuo LC, Lin JH, Xu X, Jin L, Olah TV, McLoughlin DA, King RC, Chapman KT, Tata JR. Cheng Y, et al. Among authors: lu z. Bioorg Med Chem Lett. 2002 Feb 25;12(4):529-32. doi: 10.1016/s0960-894x(01)00824-1. Bioorg Med Chem Lett. 2002. PMID: 11844665
Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-resistant viral strains.
Cheng Y, Zhang F, Rano TA, Lu Z, Schleif WA, Gabryelski L, Olsen DB, Stahlhut M, Rutkowski CA, Lin JH, Jin L, Emini EA, Chapman KT, Tata JR. Cheng Y, et al. Among authors: lu z. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2419-22. doi: 10.1016/s0960-894x(02)00424-9. Bioorg Med Chem Lett. 2002. PMID: 12161147
A new class of glycogen phosphorylase inhibitors.
Lu Z, Bohn J, Bergeron R, Deng Q, Ellsworth KP, Geissler WM, Harris G, McCann PE, McKeever B, Myers RW, Saperstein R, Willoughby CA, Yao J, Chapman K. Lu Z, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4125-8. doi: 10.1016/j.bmcl.2003.08.046. Bioorg Med Chem Lett. 2003. PMID: 14592521
Design of a novel class of biphenyl CETP inhibitors.
Lu Z, Napolitano JB, Theberge A, Ali A, Hammond ML, Tan E, Tong X, Xu SS, Latham MJ, Peterson LB, Anderson MS, Eveland SS, Guo Q, Hyland SA, Milot DP, Chen Y, Sparrow CP, Wright SD, Sinclair PJ. Lu Z, et al. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7469-72. doi: 10.1016/j.bmcl.2010.10.019. Epub 2010 Oct 15. Bioorg Med Chem Lett. 2010. PMID: 21041082
SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors.
Lu Z, Chen YH, Napolitano JB, Taylor G, Ali A, Hammond ML, Deng Q, Tan E, Tong X, Xu SS, Latham MJ, Peterson LB, Anderson MS, Eveland SS, Guo Q, Hyland SA, Milot DP, Chen Y, Sparrow CP, Wright SD, Sinclair PJ. Lu Z, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):199-203. doi: 10.1016/j.bmcl.2011.11.039. Epub 2011 Nov 16. Bioorg Med Chem Lett. 2012. PMID: 22142541
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