Hamel E - Search Results

1

Development of two novel benzoylphenylurea sulfur analogues and evidence that the microtubule-associated protein tau is predictive of their activity in pancreatic cancer.

Jimeno A, Hallur G, Chan A, Zhang X, Cusatis G, Chan F, Shah P, Chen R, Hamel E, Garrett-Mayer E, Khan S, Hidalgo M. Jimeno A, et al. Among authors: hamel e. Mol Cancer Ther. 2007 May;6(5):1509-16. doi: 10.1158/1535-7163.MCT-06-0592. Epub 2007 May 4. Mol Cancer Ther. 2007. PMID: 17483439

2

Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.

Cruz-Monserrate Z, Vervoort HC, Bai R, Newman DJ, Howell SB, Los G, Mullaney JT, Williams MD, Pettit GR, Fenical W, Hamel E. Cruz-Monserrate Z, et al. Among authors: hamel e. Mol Pharmacol. 2003 Jun;63(6):1273-80. doi: 10.1124/mol.63.6.1273. Mol Pharmacol. 2003. PMID: 12761336

3

Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously.

Gapud EJ, Bai R, Ghosh AK, Hamel E. Gapud EJ, et al. Among authors: hamel e. Mol Pharmacol. 2004 Jul;66(1):113-21. doi: 10.1124/mol.66.1.113. Mol Pharmacol. 2004. PMID: 15213302

4

Benzoylphenylurea sulfur analogues with potent antitumor activity.

Hallur G, Jimeno A, Dalrymple S, Zhu T, Jung MK, Hidalgo M, Isaacs JT, Sukumar S, Hamel E, Khan SR. Hallur G, et al. Among authors: hamel e. J Med Chem. 2006 Apr 6;49(7):2357-60. doi: 10.1021/jm051261s. J Med Chem. 2006. PMID: 16570932

5

A bifunctional colchicinoid that binds to the androgen receptor.

Sharifi N, Hamel E, Lill MA, Risbood P, Kane CT Jr, Hossain MT, Jones A, Dalton JT, Farrar WL. Sharifi N, et al. Among authors: hamel e. Mol Cancer Ther. 2007 Aug;6(8):2328-36. doi: 10.1158/1535-7163.MCT-07-0163. Mol Cancer Ther. 2007. PMID: 17699728

6

Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198.

LaVallee TM, Burke PA, Swartz GM, Hamel E, Agoston GE, Shah J, Suwandi L, Hanson AD, Fogler WE, Sidor CF, Treston AM. LaVallee TM, et al. Among authors: hamel e. Mol Cancer Ther. 2008 Jun;7(6):1472-82. doi: 10.1158/1535-7163.MCT-08-0107. Mol Cancer Ther. 2008. PMID: 18566218

7

Novel microtubule-interacting phenoxy pyridine and phenyl sulfanyl pyridine analogues for cancer therapy.

Anchoori RK, Kortenhorst MS, Hidalgo M, Sarkar T, Hallur G, Bai R, Diest PJ, Hamel E, Khan SR. Anchoori RK, et al. Among authors: hamel e. J Med Chem. 2008 Oct 9;51(19):5953-7. doi: 10.1021/jm800203e. Epub 2008 Sep 9. J Med Chem. 2008. PMID: 18778046 Free PMC article.

8

Novel hybrid nocodazole analogues as tubulin polymerization inhibitors and their antiproliferative activity.

Kale SS, Jedhe GS, Meshram SN, Santra MK, Hamel E, Sanjayan GJ. Kale SS, et al. Among authors: hamel e. Bioorg Med Chem Lett. 2015 May 1;25(9):1982-5. doi: 10.1016/j.bmcl.2015.03.019. Epub 2015 Mar 14. Bioorg Med Chem Lett. 2015. PMID: 25817588 Free PMC article.

9

Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.

Bai R, Friedman SJ, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Biochem Pharmacol. 1992 Jun 23;43(12):2637-45. doi: 10.1016/0006-2952(92)90153-a. Biochem Pharmacol. 1992. PMID: 1632820

10

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.

Kowalski RJ, Giannakakou P, Gunasekera SP, Longley RE, Day BW, Hamel E. Kowalski RJ, et al. Among authors: hamel e. Mol Pharmacol. 1997 Oct;52(4):613-22. Mol Pharmacol. 1997. PMID: 9380024

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