Lin C - Search Results

1

Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir.

Sarrazin C, Kieffer TL, Bartels D, Hanzelka B, Müh U, Welker M, Wincheringer D, Zhou Y, Chu HM, Lin C, Weegink C, Reesink H, Zeuzem S, Kwong AD. Sarrazin C, et al. Among authors: lin c. Gastroenterology. 2007 May;132(5):1767-77. doi: 10.1053/j.gastro.2007.02.037. Epub 2007 Feb 21. Gastroenterology. 2007. PMID: 17484874 Clinical Trial.

2

Combination of a hepatitis C virus NS3-NS4A protease inhibitor and alpha interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells.

Lin K, Kwong AD, Lin C. Lin K, et al. Among authors: lin c. Antimicrob Agents Chemother. 2004 Dec;48(12):4784-92. doi: 10.1128/AAC.48.12.4784-4792.2004. Antimicrob Agents Chemother. 2004. PMID: 15561857 Free PMC article.

3

VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCv replicon cells.

Lin K, Perni RB, Kwong AD, Lin C. Lin K, et al. Among authors: lin c. Antimicrob Agents Chemother. 2006 May;50(5):1813-22. doi: 10.1128/AAC.50.5.1813-1822.2006. Antimicrob Agents Chemother. 2006. PMID: 16641454 Free PMC article.

4

Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha.

Zhou Y, Müh U, Hanzelka BL, Bartels DJ, Wei Y, Rao BG, Brennan DL, Tigges AM, Swenson L, Kwong AD, Lin C. Zhou Y, et al. Among authors: lin c. J Biol Chem. 2007 Aug 3;282(31):22619-28. doi: 10.1074/jbc.M610207200. Epub 2007 Jun 6. J Biol Chem. 2007. PMID: 17556358 Free article.

5

Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3-4A serine protease.

Zhou Y, Bartels DJ, Hanzelka BL, Müh U, Wei Y, Chu HM, Tigges AM, Brennan DL, Rao BG, Swenson L, Kwong AD, Lin C. Zhou Y, et al. Among authors: lin c. Antimicrob Agents Chemother. 2008 Jan;52(1):110-20. doi: 10.1128/AAC.00863-07. Epub 2007 Oct 15. Antimicrob Agents Chemother. 2008. PMID: 17938182 Free PMC article. Clinical Trial.

6

Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects.

Bartels DJ, Zhou Y, Zhang EZ, Marcial M, Byrn RA, Pfeiffer T, Tigges AM, Adiwijaya BS, Lin C, Kwong AD, Kieffer TL. Bartels DJ, et al. Among authors: lin c. J Infect Dis. 2008 Sep 15;198(6):800-7. doi: 10.1086/591141. J Infect Dis. 2008. PMID: 18637752

7

A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants.

Adiwijaya BS, Herrmann E, Hare B, Kieffer T, Lin C, Kwong AD, Garg V, Randle JC, Sarrazin C, Zeuzem S, Caron PR. Adiwijaya BS, et al. Among authors: lin c. PLoS Comput Biol. 2010 Apr 15;6(4):e1000745. doi: 10.1371/journal.pcbi.1000745. PLoS Comput Biol. 2010. PMID: 20419154 Free PMC article.

8

In vitro phenotypic characterization of hepatitis C virus NS3 protease variants observed in clinical studies of telaprevir.

Jiang M, Mani N, Lin C, Ardzinski A, Nelson M, Reagan D, Bartels D, Zhou Y, Nicolas O, Rao BG, Müh U, Hanzelka B, Tigges A, Rijnbrand R, Kieffer TL. Jiang M, et al. Among authors: lin c. Antimicrob Agents Chemother. 2013 Dec;57(12):6236-45. doi: 10.1128/AAC.01578-13. Epub 2013 Oct 7. Antimicrob Agents Chemother. 2013. PMID: 24100495 Free PMC article.

9

Development of a sensitive RT-PCR method for amplifying and sequencing near full-length HCV genotype 1 RNA from patient samples.

Zhang EZ, Bartels DJ, Frantz JD, Seepersaud S, Lippke JA, Shames B, Zhou Y, Lin C, Kwong A, Kieffer TL. Zhang EZ, et al. Among authors: lin c. Virol J. 2013 Feb 12;10:53. doi: 10.1186/1743-422X-10-53. Virol J. 2013. PMID: 23402332 Free PMC article.

10

In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms.

Lin C, Lin K, Luong YP, Rao BG, Wei YY, Brennan DL, Fulghum JR, Hsiao HM, Ma S, Maxwell JP, Cottrell KM, Perni RB, Gates CA, Kwong AD. Lin C, et al. Among authors: lin k. J Biol Chem. 2004 Apr 23;279(17):17508-14. doi: 10.1074/jbc.M313020200. Epub 2004 Feb 6. J Biol Chem. 2004. PMID: 14766754 Free article.

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