DeGrado WF - Search Results

1

The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen.

White TC, Berny MA, Robinson DK, Yin H, DeGrado WF, Hanson SR, McCarty OJ. White TC, et al. Among authors: degrado wf. FEBS J. 2007 Mar;274(6):1481-91. doi: 10.1111/j.1742-4658.2007.05689.x. FEBS J. 2007. PMID: 17489103 Free article.

2

Arylamide derivatives as allosteric inhibitors of the integrin alpha2beta1/type I collagen interaction.

Yin H, Gerlach LO, Miller MW, Moore DT, Liu D, Vilaire G, Bennett JS, DeGrado WF. Yin H, et al. Among authors: degrado wf. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3380-2. doi: 10.1016/j.bmcl.2006.04.037. Epub 2006 May 5. Bioorg Med Chem Lett. 2006. PMID: 16678410

3

Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism.

Miller MW, Basra S, Kulp DW, Billings PC, Choi S, Beavers MP, McCarty OJ, Zou Z, Kahn ML, Bennett JS, DeGrado WF. Miller MW, et al. Among authors: degrado wf. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):719-24. doi: 10.1073/pnas.0811622106. Epub 2009 Jan 13. Proc Natl Acad Sci U S A. 2009. PMID: 19141632 Free PMC article.

4

Arylamide derivatives as peptidomimetic inhibitors of calmodulin.

Yin H, Frederick KK, Liu D, Wand AJ, Degrado WF. Yin H, et al. Among authors: degrado wf. Org Lett. 2006 Jan 19;8(2):223-5. doi: 10.1021/ol052478j. Org Lett. 2006. PMID: 16408880

5

Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb.

Yin H, Litvinov RI, Vilaire G, Zhu H, Li W, Caputo GA, Moore DT, Lear JD, Weisel JW, Degrado WF, Bennett JS. Yin H, et al. Among authors: degrado wf. J Biol Chem. 2006 Dec 1;281(48):36732-41. doi: 10.1074/jbc.M605877200. Epub 2006 Oct 10. J Biol Chem. 2006. PMID: 17032655 Free article.

6

Computationally designed peptide inhibitors of protein-protein interactions in membranes.

Caputo GA, Litvinov RI, Li W, Bennett JS, Degrado WF, Yin H. Caputo GA, et al. Among authors: degrado wf. Biochemistry. 2008 Aug 19;47(33):8600-6. doi: 10.1021/bi800687h. Epub 2008 Jul 22. Biochemistry. 2008. PMID: 18642886 Free PMC article.

7

Using two fluorescent probes to dissect the binding, insertion, and dimerization kinetics of a model membrane peptide.

Tang J, Yin H, Qiu J, Tucker MJ, DeGrado WF, Gai F. Tang J, et al. Among authors: degrado wf. J Am Chem Soc. 2009 Mar 25;131(11):3816-7. doi: 10.1021/ja809007f. J Am Chem Soc. 2009. PMID: 19256494 Free PMC article.

8

Directly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering.

Fong KP, Zhu H, Span LM, Moore DT, Yoon K, Tamura R, Yin H, DeGrado WF, Bennett JS. Fong KP, et al. Among authors: degrado wf. J Biol Chem. 2016 May 27;291(22):11706-16. doi: 10.1074/jbc.M116.716613. Epub 2016 Apr 7. J Biol Chem. 2016. PMID: 27056329 Free PMC article.

9

Small molecule inhibitors of integrin alpha2beta1.

Choi S, Vilaire G, Marcinkiewicz C, Winkler JD, Bennett JS, DeGrado WF. Choi S, et al. Among authors: degrado wf. J Med Chem. 2007 Nov 1;50(22):5457-62. doi: 10.1021/jm070252b. Epub 2007 Oct 4. J Med Chem. 2007. PMID: 17915848 Free PMC article.

10

Computational design of peptides that target transmembrane helices.

Yin H, Slusky JS, Berger BW, Walters RS, Vilaire G, Litvinov RI, Lear JD, Caputo GA, Bennett JS, DeGrado WF. Yin H, et al. Among authors: degrado wf. Science. 2007 Mar 30;315(5820):1817-22. doi: 10.1126/science.1136782. Science. 2007. PMID: 17395823

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