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Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis.
Kindmark A, Jawaid A, Harbron CG, Barratt BJ, Bengtsson OF, Andersson TB, Carlsson S, Cederbrant KE, Gibson NJ, Armstrong M, Lagerström-Fermér ME, Dellsén A, Brown EM, Thornton M, Dukes C, Jenkins SC, Firth MA, Harrod GO, Pinel TH, Billing-Clason SM, Cardon LR, March RE. Kindmark A, et al. Pharmacogenomics J. 2008 Jun;8(3):186-95. doi: 10.1038/sj.tpj.6500458. Epub 2007 May 15. Pharmacogenomics J. 2008. PMID: 17505501
A single nucleotide polymorphism in the promoter region of the osteoprotegerin gene is related to intima-media thickness of the carotid artery in hypertensive patients. The Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA).
Brändström H, Stiger F, Kahan T, Melhus H, Nyström F, öHman KP, Malmqvist K, Lind L, Kindmark A. Brändström H, et al. Among authors: kindmark a. Blood Press. 2004;13(3):152-7. doi: 10.1080/08037050410035563. Blood Press. 2004. PMID: 15223723 Free article. Clinical Trial.
A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women.
Grundberg E, Carling T, Brändström H, Huang S, Ribom EL, Ljunggren O, Mallmin H, Kindmark A. Grundberg E, et al. Among authors: kindmark a. J Clin Endocrinol Metab. 2004 Dec;89(12):6173-8. doi: 10.1210/jc.2004-0403. J Clin Endocrinol Metab. 2004. PMID: 15579774
Heterozygosity for a coding SNP in COL1A2 confers a lower BMD and an increased stroke risk.
Lindahl K, Rubin CJ, Brändström H, Karlsson MK, Holmberg A, Ohlsson C, Mellström D, Orwoll E, Mallmin H, Kindmark A, Ljunggren O. Lindahl K, et al. Among authors: kindmark a. Biochem Biophys Res Commun. 2009 Jul 10;384(4):501-5. doi: 10.1016/j.bbrc.2009.05.006. Epub 2009 May 6. Biochem Biophys Res Commun. 2009. PMID: 19426706
79 results