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Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones.
Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass CK, Ricote M. Hevener AL, et al. Among authors: gonzalez fj. J Clin Invest. 2007 Jun;117(6):1658-69. doi: 10.1172/JCI31561. Epub 2007 May 24. J Clin Invest. 2007. PMID: 17525798 Free PMC article.
Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux.
Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, Lee YH, Ricote M, Glass CK, Brewer HB Jr, Gonzalez FJ. Akiyama TE, et al. Among authors: gonzalez fj. Mol Cell Biol. 2002 Apr;22(8):2607-19. doi: 10.1128/MCB.22.8.2607-2619.2002. Mol Cell Biol. 2002. PMID: 11909955 Free PMC article.
PPARdelta regulates glucose metabolism and insulin sensitivity.
Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM. Lee CH, et al. Among authors: gonzalez fj. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3444-9. doi: 10.1073/pnas.0511253103. Epub 2006 Feb 21. Proc Natl Acad Sci U S A. 2006. PMID: 16492734 Free PMC article.
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.
Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W. Michalik L, et al. Among authors: gonzalez fj. Pharmacol Rev. 2006 Dec;58(4):726-41. doi: 10.1124/pr.58.4.5. Pharmacol Rev. 2006. PMID: 17132851 Review.
1,525 results