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Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue.
Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M. Zhang M, et al. Among authors: piccini i. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5383-92. doi: 10.1073/pnas.1419553111. Epub 2014 Dec 1. Proc Natl Acad Sci U S A. 2014. PMID: 25453094 Free PMC article.
PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.
Kirchhof P, Kahr PC, Kaese S, Piccini I, Vokshi I, Scheld HH, Rotering H, Fortmueller L, Laakmann S, Verheule S, Schotten U, Fabritz L, Brown NA. Kirchhof P, et al. Among authors: piccini i. Circ Cardiovasc Genet. 2011 Apr;4(2):123-33. doi: 10.1161/CIRCGENETICS.110.958058. Epub 2011 Jan 31. Circ Cardiovasc Genet. 2011. PMID: 21282332
Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.
Rao J, Pfeiffer MJ, Frank S, Adachi K, Piccini I, Quaranta R, Araúzo-Bravo M, Schwarz J, Schade D, Leidel S, Schöler HR, Seebohm G, Greber B. Rao J, et al. Among authors: piccini i. Cell Stem Cell. 2016 Mar 3;18(3):341-53. doi: 10.1016/j.stem.2015.11.019. Epub 2015 Dec 31. Cell Stem Cell. 2016. PMID: 26748419 Free article.
48 results