Hunt J - Search Results

1

Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.

Prag S, Parsons M, Keppler MD, Ameer-Beg SM, Barber P, Hunt J, Beavil AJ, Calvert R, Arpin M, Vojnovic B, Ng T. Prag S, et al. Among authors: hunt j. Mol Biol Cell. 2007 Aug;18(8):2935-48. doi: 10.1091/mbc.e06-11-1031. Epub 2007 May 30. Mol Biol Cell. 2007. PMID: 17538024 Free PMC article.

2

Disulfide linkage controls the affinity and stoichiometry of IgE Fcepsilon3-4 binding to FcepsilonRI.

Hunt J, Beavil RL, Calvert RA, Gould HJ, Sutton BJ, Beavil AJ. Hunt J, et al. J Biol Chem. 2005 Apr 29;280(17):16808-14. doi: 10.1074/jbc.M500965200. Epub 2005 Mar 2. J Biol Chem. 2005. PMID: 15743766 Free article.

3

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.

Holdom MD, Davies AM, Nettleship JE, Bagby SC, Dhaliwal B, Girardi E, Hunt J, Gould HJ, Beavil AJ, McDonnell JM, Owens RJ, Sutton BJ. Holdom MD, et al. Among authors: hunt j. Nat Struct Mol Biol. 2011 May;18(5):571-6. doi: 10.1038/nsmb.2044. Epub 2011 Apr 24. Nat Struct Mol Biol. 2011. PMID: 21516097 Free PMC article.

4

Analysis of the interaction between RGD-expressing adenovirus type 5 fiber knob domains and alphavbeta3 integrin reveals distinct binding profiles and intracellular trafficking.

Lord R, Parsons M, Kirby I, Beavil A, Hunt J, Sutton B, Santis G. Lord R, et al. Among authors: hunt j. J Gen Virol. 2006 Sep;87(Pt 9):2497-2505. doi: 10.1099/vir.0.81620-0. J Gen Virol. 2006. PMID: 16894187

5

Attenuation of IgE affinity for FcepsilonRI radically reduces the allergic response in vitro and in vivo.

Hunt J, Bracher MG, Shi J, Fleury S, Dombrowicz D, Gould HJ, Sutton BJ, Beavil AJ. Hunt J, et al. J Biol Chem. 2008 Oct 31;283(44):29882-7. doi: 10.1074/jbc.M804742200. Epub 2008 Aug 13. J Biol Chem. 2008. PMID: 18703499 Free PMC article.

6

A fluorescent biosensor reveals conformational changes in human immunoglobulin E Fc: implications for mechanisms of receptor binding, inhibition, and allergen recognition.

Hunt J, Keeble AH, Dale RE, Corbett MK, Beavil RL, Levitt J, Swann MJ, Suhling K, Ameer-Beg S, Sutton BJ, Beavil AJ. Hunt J, et al. J Biol Chem. 2012 May 18;287(21):17459-17470. doi: 10.1074/jbc.M111.331967. Epub 2012 Mar 22. J Biol Chem. 2012. PMID: 22442150 Free PMC article.

7

Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells.

Karagiannis SN, Bracher MG, Beavil RL, Beavil AJ, Hunt J, McCloskey N, Thompson RG, East N, Burke F, Sutton BJ, Dombrowicz D, Balkwill FR, Gould HJ. Karagiannis SN, et al. Among authors: hunt j. Cancer Immunol Immunother. 2008 Feb;57(2):247-63. doi: 10.1007/s00262-007-0371-7. Epub 2007 Jul 27. Cancer Immunol Immunother. 2008. PMID: 17657488 Free PMC article.

8

IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells.

Karagiannis SN, Bracher MG, Hunt J, McCloskey N, Beavil RL, Beavil AJ, Fear DJ, Thompson RG, East N, Burke F, Moore RJ, Dombrowicz DD, Balkwill FR, Gould HJ. Karagiannis SN, et al. Among authors: hunt j. J Immunol. 2007 Sep 1;179(5):2832-43. doi: 10.4049/jimmunol.179.5.2832. J Immunol. 2007. PMID: 17709497

9

Characterisation of an engineered trastuzumab IgE antibody and effector cell mechanisms targeting HER2/neu-positive tumour cells.

Karagiannis P, Singer J, Hunt J, Gan SK, Rudman SM, Mechtcheriakova D, Knittelfelder R, Daniels TR, Hobson PS, Beavil AJ, Spicer J, Nestle FO, Penichet ML, Gould HJ, Jensen-Jarolim E, Karagiannis SN. Karagiannis P, et al. Among authors: hunt j. Cancer Immunol Immunother. 2009 Jun;58(6):915-30. doi: 10.1007/s00262-008-0607-1. Epub 2008 Oct 22. Cancer Immunol Immunother. 2009. PMID: 18941743 Free PMC article.

10

Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcɛRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity.

Rudman SM, Josephs DH, Cambrook H, Karagiannis P, Gilbert AE, Dodev T, Hunt J, Koers A, Montes A, Taams L, Canevari S, Figini M, Blower PJ, Beavil AJ, Nicodemus CF, Corrigan C, Kaye SB, Nestle FO, Gould HJ, Spicer JF, Karagiannis SN. Rudman SM, et al. Among authors: hunt j. Clin Exp Allergy. 2011 Oct;41(10):1400-13. doi: 10.1111/j.1365-2222.2011.03770.x. Epub 2011 May 16. Clin Exp Allergy. 2011. PMID: 21569129

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