Warne PH - Search Results

1

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.

Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J. Gupta S, et al. Among authors: warne ph. Cell. 2007 Jun 1;129(5):957-68. doi: 10.1016/j.cell.2007.03.051. Cell. 2007. PMID: 17540175 Free article.

2

The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component.

Schulze A, Nicke B, Warne PH, Tomlinson S, Downward J. Schulze A, et al. Among authors: warne ph. Mol Biol Cell. 2004 Jul;15(7):3450-63. doi: 10.1091/mbc.e03-11-0807. Epub 2004 Apr 16. Mol Biol Cell. 2004. PMID: 15090615 Free PMC article.

3

CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness.

Michl P, Ramjaun AR, Pardo OE, Warne PH, Wagner M, Poulsom R, D'Arrigo C, Ryder K, Menke A, Gress T, Downward J. Michl P, et al. Among authors: warne ph. Cancer Cell. 2005 Jun;7(6):521-32. doi: 10.1016/j.ccr.2005.05.018. Cancer Cell. 2005. PMID: 15950902 Free article.

4

Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.

Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, Hancock DC. Nicke B, et al. Among authors: warne ph. Mol Cell. 2005 Dec 9;20(5):673-85. doi: 10.1016/j.molcel.2005.10.038. Mol Cell. 2005. PMID: 16337592 Free article.

5

RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression.

Castellano E, Molina-Arcas M, Krygowska AA, East P, Warne P, Nicol A, Downward J. Castellano E, et al. Nat Commun. 2016 Apr 13;7:11245. doi: 10.1038/ncomms11245. Nat Commun. 2016. PMID: 27071537 Free PMC article.

6

Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.

Swanton C, Marani M, Pardo O, Warne PH, Kelly G, Sahai E, Elustondo F, Chang J, Temple J, Ahmed AA, Brenton JD, Downward J, Nicke B. Swanton C, et al. Among authors: warne ph. Cancer Cell. 2007 Jun;11(6):498-512. doi: 10.1016/j.ccr.2007.04.011. Cancer Cell. 2007. PMID: 17560332 Free article.

7

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies.

Steckel M, Molina-Arcas M, Weigelt B, Marani M, Warne PH, Kuznetsov H, Kelly G, Saunders B, Howell M, Downward J, Hancock DC. Steckel M, et al. Among authors: warne ph. Cell Res. 2012 Aug;22(8):1227-45. doi: 10.1038/cr.2012.82. Epub 2012 May 22. Cell Res. 2012. PMID: 22613949 Free PMC article.

8

PI3K pathway dependencies in endometrioid endometrial cancer cell lines.

Weigelt B, Warne PH, Lambros MB, Reis-Filho JS, Downward J. Weigelt B, et al. Among authors: warne ph. Clin Cancer Res. 2013 Jul 1;19(13):3533-44. doi: 10.1158/1078-0432.CCR-12-3815. Epub 2013 May 14. Clin Cancer Res. 2013. PMID: 23674493 Free PMC article.

9

Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos.

Buday L, Warne PH, Downward J. Buday L, et al. Among authors: warne ph. Oncogene. 1995 Oct 5;11(7):1327-31. Oncogene. 1995. PMID: 7478553

10

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro.

Warne PH, Viciana PR, Downward J. Warne PH, et al. Nature. 1993 Jul 22;364(6435):352-5. doi: 10.1038/364352a0. Nature. 1993. PMID: 8332195

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