Konrad M - Search Results

1

Structural mechanism for substrate inhibition of the adenosine 5'-phosphosulfate kinase domain of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 and its ramifications for enzyme regulation.

Sekulic N, Konrad M, Lavie A. Sekulic N, et al. Among authors: konrad m. J Biol Chem. 2007 Jul 27;282(30):22112-21. doi: 10.1074/jbc.M701713200. Epub 2007 May 31. J Biol Chem. 2007. PMID: 17540769 Free article.

2

Structural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domains.

Li Y, Spangenberg O, Paarmann I, Konrad M, Lavie A. Li Y, et al. Among authors: konrad m. J Biol Chem. 2002 Feb 8;277(6):4159-65. doi: 10.1074/jbc.M110792200. Epub 2001 Nov 29. J Biol Chem. 2002. PMID: 11729206 Free article.

3

Structural characterization of the closed conformation of mouse guanylate kinase.

Sekulic N, Shuvalova L, Spangenberg O, Konrad M, Lavie A. Sekulic N, et al. Among authors: konrad m. J Biol Chem. 2002 Aug 16;277(33):30236-43. doi: 10.1074/jbc.M204668200. Epub 2002 May 29. J Biol Chem. 2002. PMID: 12036965 Free article.

4

Substrate-induced conformational changes in human UMP/CMP kinase.

Segura-Peña D, Sekulic N, Ort S, Konrad M, Lavie A. Segura-Peña D, et al. Among authors: konrad m. J Biol Chem. 2004 Aug 6;279(32):33882-9. doi: 10.1074/jbc.M401989200. Epub 2004 May 26. J Biol Chem. 2004. PMID: 15163660 Free article.

5

Elucidation of the active conformation of the APS-kinase domain of human PAPS synthetase 1.

Sekulic N, Dietrich K, Paarmann I, Ort S, Konrad M, Lavie A. Sekulic N, et al. Among authors: konrad m. J Mol Biol. 2007 Mar 23;367(2):488-500. doi: 10.1016/j.jmb.2007.01.025. Epub 2007 Jan 12. J Mol Biol. 2007. PMID: 17276460 Free PMC article.

6

Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides.

Sabini E, Hazra S, Konrad M, Lavie A. Sabini E, et al. Among authors: konrad m. J Med Chem. 2007 Jun 28;50(13):3004-14. doi: 10.1021/jm0700215. Epub 2007 May 27. J Med Chem. 2007. PMID: 17530837 Free PMC article.

7

Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase.

Sabini E, Hazra S, Konrad M, Lavie A. Sabini E, et al. Among authors: konrad m. J Med Chem. 2008 Jul 24;51(14):4219-25. doi: 10.1021/jm800134t. Epub 2008 Jun 21. J Med Chem. 2008. PMID: 18570408 Free PMC article.

8

The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues.

Hazra S, Konrad M, Lavie A. Hazra S, et al. Among authors: konrad m. J Med Chem. 2010 Aug 12;53(15):5792-800. doi: 10.1021/jm1005379. J Med Chem. 2010. PMID: 20684612 Free PMC article.

9

Formation of complexes between Ca2+.calmodulin and the synapse-associated protein SAP97 requires the SH3 domain-guanylate kinase domain-connecting HOOK region.

Paarmann I, Spangenberg O, Lavie A, Konrad M. Paarmann I, et al. Among authors: konrad m. J Biol Chem. 2002 Oct 25;277(43):40832-8. doi: 10.1074/jbc.M205618200. Epub 2002 Aug 19. J Biol Chem. 2002. PMID: 12189141 Free article.

10

Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase.

Lavie A, Konrad M. Lavie A, et al. Among authors: konrad m. Mini Rev Med Chem. 2004 May;4(4):351-9. doi: 10.2174/1389557043403981. Mini Rev Med Chem. 2004. PMID: 15134538 Review.

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