Raymer B - Search Results

1

Total synthesis of (+)-azaspiracid-1. Part II: synthesis of the EFGHI sulfone and completion of the synthesis.

Evans DA, Dunn TB, Kvaernø L, Beauchemin A, Raymer B, Olhava EJ, Mulder JA, Juhl M, Kagechika K, Favor DA. Evans DA, et al. Among authors: raymer b. Angew Chem Int Ed Engl. 2007;46(25):4698-703. doi: 10.1002/anie.200701520. Angew Chem Int Ed Engl. 2007. PMID: 17546578 No abstract available.

2

Total synthesis of (+)-azaspiracid-1. Part I: Synthesis of the fully elaborated ABCD aldehyde.

Evans DA, Kvaernø L, Mulder JA, Raymer B, Dunn TB, Beauchemin A, Olhava EJ, Juhl M, Kagechika K. Evans DA, et al. Among authors: raymer b. Angew Chem Int Ed Engl. 2007;46(25):4693-7. doi: 10.1002/anie.200701515. Angew Chem Int Ed Engl. 2007. PMID: 17546577 No abstract available.

3

Total synthesis of (+)-azaspiracid-1. An exhibition of the intricacies of complex molecule synthesis.

Evans DA, Kvaernø L, Dunn TB, Beauchemin A, Raymer B, Mulder JA, Olhava EJ, Juhl M, Kagechika K, Favor DA. Evans DA, et al. Among authors: raymer b. J Am Chem Soc. 2008 Dec 3;130(48):16295-309. doi: 10.1021/ja804659n. J Am Chem Soc. 2008. PMID: 19006391 Free PMC article.

4

Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.

McClure KF, Piotrowski DW, Petersen D, Wei L, Xiao J, Londregan AT, Kamlet AS, Dechert-Schmitt AM, Raymer B, Ruggeri RB, Canterbury D, Limberakis C, Liras S, DaSilva-Jardine P, Dullea RG, Loria PM, Reidich B, Salatto CT, Eng H, Kimoto E, Atkinson K, King-Ahmad A, Scott D, Beaumont K, Chabot JR, Bolt MW, Maresca K, Dahl K, Arakawa R, Takano A, Halldin C. McClure KF, et al. Among authors: raymer b. Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16218-16222. doi: 10.1002/anie.201708744. Epub 2017 Nov 24. Angew Chem Int Ed Engl. 2017. PMID: 29073340

5

Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase.

Raymer B, Kavana M, Price A, Wang B, Corcoran L, Kulathila R, Groarke J, Mann T. Raymer B, et al. Bioorg Med Chem Lett. 2009 May 15;19(10):2804-7. doi: 10.1016/j.bmcl.2009.03.107. Epub 2009 Mar 26. Bioorg Med Chem Lett. 2009. PMID: 19359168

6

Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9.

Londregan AT, Aspnes G, Limberakis C, Loria PM, McClure KF, Petersen DN, Raymer B, Ruggeri RB, Wei L, Xiao J, Piotrowski DW. Londregan AT, et al. Among authors: raymer b. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3685-3688. doi: 10.1016/j.bmcl.2018.10.029. Epub 2018 Oct 22. Bioorg Med Chem Lett. 2018. PMID: 30482620

7

Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).

Huard K, Ahn K, Amor P, Beebe DA, Borzilleri KA, Chrunyk BA, Coffey SB, Cong Y, Conn EL, Culp JS, Dowling MS, Gorgoglione MF, Gutierrez JA, Knafels JD, Lachapelle EA, Pandit J, Parris KD, Perez S, Pfefferkorn JA, Price DA, Raymer B, Ross TT, Shavnya A, Smith AC, Subashi TA, Tesz GJ, Thuma BA, Tu M, Weaver JD, Weng Y, Withka JM, Xing G, Magee TV. Huard K, et al. Among authors: raymer b. J Med Chem. 2017 Sep 28;60(18):7835-7849. doi: 10.1021/acs.jmedchem.7b00947. Epub 2017 Sep 11. J Med Chem. 2017. PMID: 28853885

8

Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.

Futatsugi K, Smith AC, Tu M, Raymer B, Ahn K, Coffey SB, Dowling MS, Fernando DP, Gutierrez JA, Huard K, Jasti J, Kalgutkar AS, Knafels JD, Pandit J, Parris KD, Perez S, Pfefferkorn JA, Price DA, Ryder T, Shavnya A, Stock IA, Tsai AS, Tesz GJ, Thuma BA, Weng Y, Wisniewska HM, Xing G, Zhou J, Magee TV. Futatsugi K, et al. Among authors: raymer b. J Med Chem. 2020 Nov 25;63(22):13546-13560. doi: 10.1021/acs.jmedchem.0c00944. Epub 2020 Sep 27. J Med Chem. 2020. PMID: 32910646

9

Small molecule and peptide therapies for chronic heart failure: a patent review (2011 - 2014).

Raymer B, Ebner D. Raymer B, et al. Expert Opin Ther Pat. 2015;25(10):1175-90. doi: 10.1517/13543776.2015.1061997. Epub 2015 Jul 14. Expert Opin Ther Pat. 2015. PMID: 26173447 Review.

10

Sleep modulating agents.

Choi Y, Raymer BK. Choi Y, et al. Among authors: raymer bk. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2025-2033. doi: 10.1016/j.bmcl.2019.06.043. Epub 2019 Jun 24. Bioorg Med Chem Lett. 2019. PMID: 31307886 Review.

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