Graziano A - Search Results

1

4-Amino-5-vinyl-3(2H)-pyridazinones and analogues as potent antinociceptive agents: Synthesis, SARs, and preliminary studies on the mechanism of action.

Vergelli C, Giovannoni MP, Pieretti S, Di Giannuario A, Dal Piaz V, Biagini P, Biancalani C, Graziano A, Cesari N. Vergelli C, et al. Among authors: graziano a. Bioorg Med Chem. 2007 Aug 15;15(16):5563-75. doi: 10.1016/j.bmc.2007.05.035. Epub 2007 May 18. Bioorg Med Chem. 2007. PMID: 17548197

2

Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction.

Giovannoni MP, Vergelli C, Biancalani C, Cesari N, Graziano A, Biagini P, Gracia J, Gavaldà A, Dal Piaz V. Giovannoni MP, et al. Among authors: graziano a. J Med Chem. 2006 Aug 24;49(17):5363-71. doi: 10.1021/jm060265+. J Med Chem. 2006. PMID: 16913726

3

Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action.

Cesari N, Biancalani C, Vergelli C, Dal Piaz V, Graziano A, Biagini P, Ghelardini C, Galeotti N, Giovannoni MP. Cesari N, et al. Among authors: graziano a. J Med Chem. 2006 Dec 28;49(26):7826-35. doi: 10.1021/jm060743g. J Med Chem. 2006. PMID: 17181165

4

4-amino-5-substituted-3(2H)-pyridazinones as orally active antinociceptive agents: synthesis and studies on the mechanism of action.

Giovannoni MP, Cesari N, Vergelli C, Graziano A, Biancalani C, Biagini P, Ghelardini C, Vivoli E, Dal Piaz V. Giovannoni MP, et al. Among authors: graziano a. J Med Chem. 2007 Aug 9;50(16):3945-53. doi: 10.1021/jm070161e. Epub 2007 Jul 13. J Med Chem. 2007. PMID: 17629262

5

Synthesis of pyrrolo[2,3-d]pyridazinones as potent, subtype selective PDE4 inhibitors.

Giovannoni MP, Cesari N, Graziano A, Vergelli C, Biancalani C, Biagini P, Dal Piaz V. Giovannoni MP, et al. Among authors: graziano a. J Enzyme Inhib Med Chem. 2007 Jun;22(3):309-18. doi: 10.1080/14756360601114700. J Enzyme Inhib Med Chem. 2007. PMID: 17674813 Free article.

6

6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors.

Cilibrizzi A, Quinn MT, Kirpotina LN, Schepetkin IA, Holderness J, Ye RD, Rabiet MJ, Biancalani C, Cesari N, Graziano A, Vergelli C, Pieretti S, Dal Piaz V, Giovannoni MP. Cilibrizzi A, et al. Among authors: graziano a. J Med Chem. 2009 Aug 27;52(16):5044-57. doi: 10.1021/jm900592h. J Med Chem. 2009. PMID: 19639995 Free PMC article.

7

Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain.

Biancalani C, Giovannoni MP, Pieretti S, Cesari N, Graziano A, Vergelli C, Cilibrizzi A, Di Gianuario A, Colucci M, Mangano G, Garrone B, Polenzani L, Dal Piaz V. Biancalani C, et al. Among authors: graziano a. J Med Chem. 2009 Dec 10;52(23):7397-409. doi: 10.1021/jm900458r. J Med Chem. 2009. PMID: 19788200

8

Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity.

Biagini P, Biancalani C, Graziano A, Cesari N, Giovannoni MP, Cilibrizzi A, Dal Piaz V, Vergelli C, Crocetti L, Delcanale M, Armani E, Rizzi A, Puccini P, Gallo PM, Spinabelli D, Caruso P. Biagini P, et al. Among authors: graziano a. Bioorg Med Chem. 2010 May 15;18(10):3506-17. doi: 10.1016/j.bmc.2010.03.066. Epub 2010 Mar 31. Bioorg Med Chem. 2010. PMID: 20413313

9

Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands.

Giovannoni MP, Vergelli C, Cilibrizzi A, Crocetti L, Biancalani C, Graziano A, Dal Piaz V, Loza MI, Cadavid MI, Díaz JL, Gavaldà A. Giovannoni MP, et al. Among authors: graziano a. Bioorg Med Chem. 2010 Nov 15;18(22):7890-9. doi: 10.1016/j.bmc.2010.09.043. Epub 2010 Sep 22. Bioorg Med Chem. 2010. PMID: 20937560

10

Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase.

Crocetti L, Giovannoni MP, Schepetkin IA, Quinn MT, Khlebnikov AI, Cilibrizzi A, Piaz VD, Graziano A, Vergelli C. Crocetti L, et al. Among authors: graziano a. Bioorg Med Chem. 2011 Aug 1;19(15):4460-72. doi: 10.1016/j.bmc.2011.06.036. Epub 2011 Jul 7. Bioorg Med Chem. 2011. PMID: 21741848 Free PMC article.

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