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Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity.
Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang SH, Zhong Z, Shen Y, Simpkins JW, Tanzi RE. Tesco G, et al. Among authors: hiltunen m. Neuron. 2007 Jun 7;54(5):721-37. doi: 10.1016/j.neuron.2007.05.012. Neuron. 2007. PMID: 17553422 Free PMC article.
Family-based association between Alzheimer's disease and variants in UBQLN1.
Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, Becker KD, Blacker D, Tanzi RE. Bertram L, et al. Among authors: hiltunen m. N Engl J Med. 2005 Mar 3;352(9):884-94. doi: 10.1056/NEJMoa042765. N Engl J Med. 2005. PMID: 15745979 Free article.
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.
Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Hiltunen M, et al. J Biol Chem. 2006 Oct 27;281(43):32240-53. doi: 10.1074/jbc.M603106200. Epub 2006 Aug 31. J Biol Chem. 2006. PMID: 16945923 Free article.
Effects of ubiquilin 1 on the unfolded protein response.
Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE. Lu A, et al. Among authors: hiltunen m. J Mol Neurosci. 2009 May;38(1):19-30. doi: 10.1007/s12031-008-9155-6. Epub 2008 Oct 25. J Mol Neurosci. 2009. PMID: 18953672
CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.
Giedraitis V, Glaser A, Sarajärvi T, Brundin R, Gunnarsson MD, Schjeide BM, Tanzi RE, Helisalmi S, Pirttilä T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M. Giedraitis V, et al. Among authors: hiltunen m. Neurosci Lett. 2010 Jan 22;469(2):265-7. doi: 10.1016/j.neulet.2009.12.011. Epub 2009 Dec 23. Neurosci Lett. 2010. PMID: 20005921 Free PMC article.
398 results