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Manipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substance seeking behavior, a subtype of Reward Deficiency Syndrome (RDS), is dependent upon gene polymorphisms: a hypothesis.
Blum K, Chen TJ, Meshkin B, Waite RL, Downs BW, Blum SH, Mengucci JF, Arcuri V, Braverman ER, Palomo T. Blum K, et al. Among authors: waite rl. Med Hypotheses. 2007;69(5):1054-60. doi: 10.1016/j.mehy.2006.12.062. Epub 2007 Apr 30. Med Hypotheses. 2007. PMID: 17467918
Hypothesizing that brain reward circuitry genes are genetic antecedents of pain sensitivity and critical diagnostic and pharmacogenomic treatment targets for chronic pain conditions.
Chen AL, Chen TJ, Waite RL, Reinking J, Tung HL, Rhoades P, Downs BW, Braverman E, Braverman D, Kerner M, Blum SH, DiNubile N, Smith D, Oscar-Berman M, Prihoda TJ, Floyd JB, O'Brien D, Liu HH, Blum K. Chen AL, et al. Among authors: waite rl. Med Hypotheses. 2009 Jan;72(1):14-22. doi: 10.1016/j.mehy.2008.07.059. Epub 2008 Oct 31. Med Hypotheses. 2009. PMID: 18951726 Free PMC article. Review.
Neurogenetics and clinical evidence for the putative activation of the brain reward circuitry by a neuroadaptagen: proposing an addiction candidate gene panel map.
Chen TJ, Blum K, Chen AL, Bowirrat A, Downs WB, Madigan MA, Waite RL, Bailey JA, Kerner M, Yeldandi S, Majmundar N, Giordano J, Morse S, Miller D, Fornari F, Braverman ER. Chen TJ, et al. Among authors: waite rl. J Psychoactive Drugs. 2011 Apr-Jun;43(2):108-27. doi: 10.1080/02791072.2011.587393. J Psychoactive Drugs. 2011. PMID: 21858957
Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary.
Blum K, Chen AL, Chen TJ, Braverman ER, Reinking J, Blum SH, Cassel K, Downs BW, Waite RL, Williams L, Prihoda TJ, Kerner MM, Palomo T, Comings DE, Tung H, Rhoades P, Oscar-Berman M. Blum K, et al. Among authors: waite rl. Theor Biol Med Model. 2008 Nov 12;5:24. doi: 10.1186/1742-4682-5-24. Theor Biol Med Model. 2008. PMID: 19014506 Free PMC article. Review.
Attention-deficit-hyperactivity disorder and reward deficiency syndrome.
Blum K, Chen AL, Braverman ER, Comings DE, Chen TJ, Arcuri V, Blum SH, Downs BW, Waite RL, Notaro A, Lubar J, Williams L, Prihoda TJ, Palomo T, Oscar-Berman M. Blum K, et al. Among authors: waite rl. Neuropsychiatr Dis Treat. 2008 Oct;4(5):893-918. doi: 10.2147/ndt.s2627. Neuropsychiatr Dis Treat. 2008. PMID: 19183781 Free PMC article.
38 results