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Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels.
Routaboul C, Norez C, Melin P, Molina MC, Boucherle B, Bossard F, Noel S, Robert R, Gauthier C, Becq F, Décout JL. Routaboul C, et al. Among authors: boucherle b. J Pharmacol Exp Ther. 2007 Sep;322(3):1023-35. doi: 10.1124/jpet.107.123307. Epub 2007 Jun 19. J Pharmacol Exp Ther. 2007. PMID: 17578899
A One-Pot Synthesis of Highly Functionalized Purines.
Zelli R, Zeinyeh W, Haudecoeur R, Alliot J, Boucherle B, Callebaut I, Décout JL. Zelli R, et al. Among authors: boucherle b. Org Lett. 2017 Dec 1;19(23):6360-6363. doi: 10.1021/acs.orglett.7b03209. Epub 2017 Nov 10. Org Lett. 2017. PMID: 29125774
Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.
Froux L, Elbahnsi A, Boucherle B, Billet A, Baatallah N, Hoffmann B, Alliot J, Zelli R, Zeinyeh W, Haudecoeur R, Chevalier B, Fortuné A, Mirval S, Simard C, Lehn P, Mornon JP, Hinzpeter A, Becq F, Callebaut I, Décout JL. Froux L, et al. Among authors: boucherle b. Eur J Med Chem. 2020 Mar 15;190:112116. doi: 10.1016/j.ejmech.2020.112116. Epub 2020 Feb 9. Eur J Med Chem. 2020. PMID: 32078860
Arylthiosemicarbazones as antileishmanial agents.
Manzano JI, Cochet F, Boucherle B, Gómez-Pérez V, Boumendjel A, Gamarro F, Peuchmaur M. Manzano JI, et al. Among authors: boucherle b. Eur J Med Chem. 2016 Nov 10;123:161-170. doi: 10.1016/j.ejmech.2016.07.014. Epub 2016 Jul 14. Eur J Med Chem. 2016. PMID: 27475107
25 results