Sullivan NR - Search Results

1

Pharmacological characterization of the muscarinic agonist (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983) in in vitro and in vivo models of chronic pain.

Sullivan NR, Leventhal L, Harrison J, Smith VA, Cummons TA, Spangler TB, Sun SC, Lu P, Uveges AJ, Strassle BW, Piesla MJ, Ramdass R, Barry A, Schantz J, Adams W, Whiteside GT, Adedoyin A, Jones PG. Sullivan NR, et al. J Pharmacol Exp Ther. 2007 Sep;322(3):1294-304. doi: 10.1124/jpet.106.118604. Epub 2007 Jun 22. J Pharmacol Exp Ther. 2007. PMID: 17586724

2

Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).

O'Neill DJ, Adedoyin A, Bray JA, Deecher DC, Fensome A, Goldberg JA, Harrison J, Leventhal L, Mann C, Mark L, Nogle L, Sullivan NR, Spangler TB, Terefenko EA, Trybulski EJ, Uveges AJ, Vu A, Whiteside GT, Zhang P. O'Neill DJ, et al. Among authors: sullivan nr. J Med Chem. 2011 Oct 13;54(19):6824-31. doi: 10.1021/jm200733r. Epub 2011 Sep 14. J Med Chem. 2011. PMID: 21916421

3

Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).

O'Neill DJ, Adedoyin A, Alfinito PD, Bray JA, Cosmi S, Deecher DC, Fensome A, Harrison J, Leventhal L, Mann C, McComas CC, Sullivan NR, Spangler TB, Uveges AJ, Trybulski EJ, Whiteside GT, Zhang P. O'Neill DJ, et al. Among authors: sullivan nr. J Med Chem. 2010 Jun 10;53(11):4511-21. doi: 10.1021/jm100053t. J Med Chem. 2010. PMID: 20462211

4

Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines.

Mahaney PE, Vu AT, McComas CC, Zhang P, Nogle LM, Watts WL, Sarkahian A, Leventhal L, Sullivan NR, Uveges AJ, Trybulski EJ. Mahaney PE, et al. Among authors: sullivan nr. Bioorg Med Chem. 2006 Dec 15;14(24):8455-66. doi: 10.1016/j.bmc.2006.08.039. Epub 2006 Sep 14. Bioorg Med Chem. 2006. PMID: 16973367

5

Tandospirone activates neuroendocrine and ERK (MAP kinase) signaling pathways specifically through 5-HT1A receptor mechanisms in vivo.

Sullivan NR, Crane JW, Damjanoska KJ, Carrasco GA, D'Souza DN, Garcia F, Van de Kar LD. Sullivan NR, et al. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jan;371(1):18-26. doi: 10.1007/s00210-004-1005-7. Epub 2005 Jan 18. Naunyn Schmiedebergs Arch Pharmacol. 2005. PMID: 15655673

6

Agonist induced-phosphorylation of Galpha11 protein reduces coupling to 5-HT2A receptors.

Shi J, Damjanoska KJ, Singh RK, Carrasco GA, Garcia F, Grippo AJ, Landry M, Sullivan NR, Battaglia G, Muma NA. Shi J, et al. Among authors: sullivan nr. J Pharmacol Exp Ther. 2007 Oct;323(1):248-56. doi: 10.1124/jpet.107.122317. Epub 2007 Jul 23. J Pharmacol Exp Ther. 2007. PMID: 17646429

7

Estrogen reduces serotonin-1A receptor-mediated oxytocin release and Galpha(i/o/z) proteins in the hypothalamus of ovariectomized rats.

D'Souza DN, Zhang Y, Damjanoska KJ, Carrasco GA, Sullivan NR, Garcia F, Battaglia G, Doncarlos LL, Muma NA, Van de Kar LD. D'Souza DN, et al. Among authors: sullivan nr. Neuroendocrinology. 2004;80(1):31-41. doi: 10.1159/000080795. Neuroendocrinology. 2004. PMID: 15385710

8

Chronic mild stress induces behavioral and physiological changes, and may alter serotonin 1A receptor function, in male and cycling female rats.

Grippo AJ, Sullivan NR, Damjanoska KJ, Crane JW, Carrasco GA, Shi J, Chen Z, Garcia F, Muma NA, Van de Kar LD. Grippo AJ, et al. Among authors: sullivan nr. Psychopharmacology (Berl). 2005 Jun;179(4):769-80. doi: 10.1007/s00213-004-2103-4. Epub 2004 Dec 24. Psychopharmacology (Berl). 2005. PMID: 15619113

9

Alterations in 5-HT2A receptor signaling in male and female transgenic rats over-expressing either Gq or RGS-insensitive Gq protein.

Shi J, Damjanoska KJ, Zemaitaitis B, Garcia F, Carrasco G, Sullivan NR, She Y, Young KH, Battaglia G, Van De kar LD, Howland DS, Muma NA. Shi J, et al. Among authors: sullivan nr. Neuropharmacology. 2006 Sep;51(3):524-35. doi: 10.1016/j.neuropharm.2006.04.012. Neuropharmacology. 2006. PMID: 16769091

10

5-HT1A receptors mediate (+)8-OH-DPAT-stimulation of extracellular signal-regulated kinase (MAP kinase) in vivo in rat hypothalamus: time dependence and regional differences.

Crane JW, Shimizu K, Carrasco GA, Garcia F, Jia C, Sullivan NR, D'Souza DN, Zhang Y, Van de Kar LD, Muma NA, Battaglia G. Crane JW, et al. Among authors: sullivan nr. Brain Res. 2007 Dec 5;1183:51-9. doi: 10.1016/j.brainres.2007.07.101. Epub 2007 Sep 29. Brain Res. 2007. PMID: 17976547

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