Lonial S - Search Results

1

The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway.

Elrod HA, Lin YD, Yue P, Wang X, Lonial S, Khuri FR, Sun SY. Elrod HA, et al. Among authors: lonial s. Mol Cancer Ther. 2007 Jul;6(7):2029-38. doi: 10.1158/1535-7163.MCT-07-0004. Epub 2007 Jun 29. Mol Cancer Ther. 2007. PMID: 17604333

2

The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT.

David E, Sun SY, Waller EK, Chen J, Khuri FR, Lonial S. David E, et al. Among authors: lonial s. Blood. 2005 Dec 15;106(13):4322-9. doi: 10.1182/blood-2005-06-2584. Epub 2005 Aug 23. Blood. 2005. PMID: 16118318 Free article.

3

14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.

Dong S, Kang S, Gu TL, Kardar S, Fu H, Lonial S, Khoury HJ, Khuri F, Chen J. Dong S, et al. Among authors: lonial s. Blood. 2007 Jul 1;110(1):360-9. doi: 10.1182/blood-2006-12-065615. Epub 2007 Mar 27. Blood. 2007. PMID: 17389761 Free PMC article.

4

The farnesyltransferase inhibitor R115777 up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer cells.

Qiu Y, Liu X, Zou W, Yue P, Lonial S, Khuri FR, Sun SY. Qiu Y, et al. Among authors: lonial s. Cancer Res. 2007 May 15;67(10):4973-80. doi: 10.1158/0008-5472.CAN-06-4044. Cancer Res. 2007. PMID: 17510428

5

The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells.

Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, Sun SY. Liu X, et al. Among authors: lonial s. Cancer Res. 2007 May 15;67(10):4981-8. doi: 10.1158/0008-5472.CAN-06-4274. Cancer Res. 2007. PMID: 17510429

6

FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.

Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J. Kang S, et al. Among authors: lonial s. Cancer Cell. 2007 Sep;12(3):201-14. doi: 10.1016/j.ccr.2007.08.003. Cancer Cell. 2007. PMID: 17785202 Free PMC article.

7

PI3 kinase/AKT pathway as a therapeutic target in multiple myeloma.

Harvey RD, Lonial S. Harvey RD, et al. Among authors: lonial s. Future Oncol. 2007 Dec;3(6):639-47. doi: 10.2217/14796694.3.6.639. Future Oncol. 2007. PMID: 18041916 Review.

8

Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors.

David E, Sinha R, Chen J, Sun SY, Kaufman JL, Lonial S. David E, et al. Among authors: lonial s. Clin Cancer Res. 2008 Aug 15;14(16):5090-8. doi: 10.1158/1078-0432.CCR-08-0016. Clin Cancer Res. 2008. PMID: 18698026

9

Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy.

Fu L, Kim YA, Wang X, Wu X, Yue P, Lonial S, Khuri FR, Sun SY. Fu L, et al. Among authors: lonial s. Cancer Res. 2009 Dec 1;69(23):8967-76. doi: 10.1158/0008-5472.CAN-09-2190. Epub 2009 Nov 17. Cancer Res. 2009. PMID: 19920197 Free PMC article.

10

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.

Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, Khuri FR, Gilliland DG, Cantley LC, Kaufman J, Chen J. Hitosugi T, et al. Among authors: lonial s. Sci Signal. 2009 Nov 17;2(97):ra73. doi: 10.1126/scisignal.2000431. Sci Signal. 2009. PMID: 19920251 Free PMC article.

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