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Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms.
Gills JJ, Castillo SS, Zhang C, Petukhov PA, Memmott RM, Hollingshead M, Warfel N, Han J, Kozikowski AP, Dennis PA. Gills JJ, et al. Among authors: hollingshead m. J Biol Chem. 2007 Sep 14;282(37):27020-27029. doi: 10.1074/jbc.M701108200. Epub 2007 Jul 13. J Biol Chem. 2007. PMID: 17631503 Free article.
Isoform- and Phosphorylation-specific Multiplexed Quantitative Pharmacodynamics of Drugs Targeting PI3K and MAPK Signaling in Xenograft Models and Clinical Biopsies.
Herrick WG, Kilpatrick CL, Hollingshead MG, Esposito D, O'Sullivan Coyne G, Gross AM, Johnson BC, Chen AP, Widemann BC, Doroshow JH, Parchment RE, Srivastava AK. Herrick WG, et al. Among authors: hollingshead mg. Mol Cancer Ther. 2021 Apr;20(4):749-760. doi: 10.1158/1535-7163.MCT-20-0566. Epub 2021 Feb 3. Mol Cancer Ther. 2021. PMID: 33536190 Free PMC article.
145 results