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Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting.
Plaza-Menacho I, Mologni L, Sala E, Gambacorti-Passerini C, Magee AI, Links TP, Hofstra RM, Barford D, Isacke CM. Plaza-Menacho I, et al. Among authors: links tp. J Biol Chem. 2007 Oct 5;282(40):29230-40. doi: 10.1074/jbc.M703461200. Epub 2007 Jul 30. J Biol Chem. 2007. PMID: 17664273 Free article.
RET/PTC rearrangement is prevalent in follicular Hürthle cell carcinomas.
de Vries MM, Celestino R, Castro P, Eloy C, Máximo V, van der Wal JE, Plukker JT, Links TP, Hofstra RM, Sobrinho-Simões M, Soares P. de Vries MM, et al. Among authors: links tp. Histopathology. 2012 Nov;61(5):833-43. doi: 10.1111/j.1365-2559.2012.04276.x. Epub 2012 Jul 17. Histopathology. 2012. PMID: 22803838 Review.
An introduction to managing medullary thyroid cancer.
de Groot JW, Links TP, Hofstra RM, Plukker JT. de Groot JW, et al. Among authors: links tp. Hered Cancer Clin Pract. 2006 Jul 15;4(3):115-25. doi: 10.1186/1897-4287-4-3-115. Hered Cancer Clin Pract. 2006. PMID: 20223015 Free PMC article.
Oncological implications of RET gene mutations in Hirschsprung's disease.
Sijmons RH, Hofstra RM, Wijburg FA, Links TP, Zwierstra RP, Vermey A, Aronson DC, Tan-Sindhunata G, Brouwers-Smalbraak GJ, Maas SM, Buys CH. Sijmons RH, et al. Among authors: links tp. Gut. 1998 Oct;43(4):542-7. doi: 10.1136/gut.43.4.542. Gut. 1998. PMID: 9824583 Free PMC article.
334 results