The cell surface expression level of the human interleukin-5 receptor alpha subunit determines the agonistic/antagonistic balance of the human interleukin-5 E13Q mutein.
Van Ostade X, Van der Heyden J, Verhee A, Vandekerckhove J, Tavernier J.
Van Ostade X, et al. Among authors: verhee a.
Eur J Biochem. 1999 Feb;259(3):954-60. doi: 10.1046/j.1432-1327.1999.00148.x.
Eur J Biochem. 1999.
PMID: 10092887
Free article.
The human interleukin-5 (IL-5) receptor consists of an alpha-chain that specifically binds the ligand with intermediate affinity, and a beta c-chain, that associates with the IL-5/IL-5R alpha complex, leading to a high-affinity, signal transducing receptor complex. …
The human interleukin-5 (IL-5) receptor consists of an alpha-chain that specifically binds the ligand with intermediate affinity, and a …