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Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit.
Jiang Y, Chen CA, Lu K, Daniewska I, De Leon J, Kong R, Forray C, Li B, Hegde LG, Wolinsky TD, Craig DA, Wetzel JM, Andersen K, Marzabadi MR. Jiang Y, et al. Among authors: chen ca. J Med Chem. 2007 Aug 9;50(16):3870-82. doi: 10.1021/jm060381c. J Med Chem. 2007. PMID: 17668921
cis-1-Oxo-heterocyclyl-4-amido cyclohexane derivatives as NPY5 receptor antagonists.
Burns JF, Chen B, Chen CA, Doller D, Edelmenky E, Jiang Y, Peterson JM, Sabio M, Weiss J, White AD, Wu L, Bhardwaj R, Chandrasena G, Boyle NJ, Huang X. Burns JF, et al. Among authors: chen ca, chen b. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1458-61. doi: 10.1016/j.bmcl.2014.02.023. Epub 2014 Feb 15. Bioorg Med Chem Lett. 2014. PMID: 24582476
Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.
Safina BS, McKerrall SJ, Sun S, Chen CA, Chowdhury S, Jia Q, Li J, Zenova AY, Andrez JC, Bankar G, Bergeron P, Chang JH, Chang E, Chen J, Dean R, Decker SM, DiPasquale A, Focken T, Hemeon I, Khakh K, Kim A, Kwan R, Lindgren A, Lin S, Maher J, Mezeyova J, Misner D, Nelkenbrecher K, Pang J, Reese R, Shields SD, Sojo L, Sheng T, Verschoof H, Waldbrook M, Wilson MS, Xie Z, Young C, Zabka TS, Hackos DH, Ortwine DF, White AD, Johnson JP Jr, Robinette CL, Dehnhardt CM, Cohen CJ, Sutherlin DP. Safina BS, et al. Among authors: chen j, chen ca. J Med Chem. 2021 Mar 25;64(6):2953-2966. doi: 10.1021/acs.jmedchem.1c00049. Epub 2021 Mar 8. J Med Chem. 2021. PMID: 33682420
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.
Focken T, Chowdhury S, Zenova A, Grimwood ME, Chabot C, Sheng T, Hemeon I, Decker SM, Wilson M, Bichler P, Jia Q, Sun S, Young C, Lin S, Goodchild SJ, Shuart NG, Chang E, Xie Z, Li B, Khakh K, Bankar G, Waldbrook M, Kwan R, Nelkenbrecher K, Karimi Tari P, Chahal N, Sojo L, Robinette CL, White AD, Chen CA, Zhang Y, Pang J, Chang JH, Hackos DH, Johnson JP Jr, Cohen CJ, Ortwine DF, Sutherlin DP, Dehnhardt CM, Safina BS. Focken T, et al. Among authors: chen ca. J Med Chem. 2018 Jun 14;61(11):4810-4831. doi: 10.1021/acs.jmedchem.7b01826. Epub 2018 May 23. J Med Chem. 2018. PMID: 29737846
Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity.
Sun S, Jia Q, Zenova AY, Wilson MS, Chowdhury S, Focken T, Li J, Decker S, Grimwood ME, Andrez JC, Hemeon I, Sheng T, Chen CA, White A, Hackos DH, Deng L, Bankar G, Khakh K, Chang E, Kwan R, Lin S, Nelkenbrecher K, Sellers BD, DiPasquale AG, Chang J, Pang J, Sojo L, Lindgren A, Waldbrook M, Xie Z, Young C, Johnson JP, Robinette CL, Cohen CJ, Safina BS, Sutherlin DP, Ortwine DF, Dehnhardt CM. Sun S, et al. Among authors: chen ca. J Med Chem. 2019 Jan 24;62(2):908-927. doi: 10.1021/acs.jmedchem.8b01621. Epub 2018 Dec 21. J Med Chem. 2019. PMID: 30499663
BNT162b2 mRNA vaccine elicits robust virus-specific antibodies but poor cross-protective CD8+ memory T cell responses in adolescents with type 1 diabetes.
Shen CF, Chang PD, Chou YY, Wang SW, Pan YW, Chen CA, Lin CW, Tsai BY, Tsai PJ, Liu CC, Cheng CM, Ko WC, Shieh CC; Taiwan Pediatric Infectious Disease Alliance (TPIDA). Shen CF, et al. Among authors: chen ca. J Microbiol Immunol Infect. 2025 Jan 3:S1684-1182(25)00001-5. doi: 10.1016/j.jmii.2024.12.009. Online ahead of print. J Microbiol Immunol Infect. 2025. PMID: 39765453
Cost and activity analysis for a citywide patient navigation intervention to engage underserved patients in breast cancer treatment: Findings from the Translating Research Into Practice study.
Rajabiun S, Cabral HJ, Chen CA, Lloyd-Travaglini C, Dugas JN, Amburgey D, Fitzgerald M, Lemon SC, Haas JS, Freund KM, Battaglia T; TRIP Consortium. Rajabiun S, et al. Among authors: chen ca. Cancer. 2025 Jan 1;131(1):e35671. doi: 10.1002/cncr.35671. Cancer. 2025. PMID: 39748471 Free PMC article.
Tunable Electron Correlation in Epitaxial 1T-TaS2 Spirals.
Chen CJ, Chen CA, Cheng YH, Chung CT, Lin YT, Chiang YC, Lee TK, Lee YH. Chen CJ, et al. Among authors: chen ca. Adv Mater. 2024 Dec 17:e2413926. doi: 10.1002/adma.202413926. Online ahead of print. Adv Mater. 2024. PMID: 39690786
813 results