Druzhyna NM - Search Results

1

Altering DNA base excision repair: use of nuclear and mitochondrial-targeted N-methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents.

Harrison JF, Rinne ML, Kelley MR, Druzhyna NM, Wilson GL, Ledoux SP. Harrison JF, et al. Among authors: druzhyna nm. Glia. 2007 Nov 1;55(14):1416-25. doi: 10.1002/glia.20556. Glia. 2007. PMID: 17674369 Free PMC article.

2

Mitochondrial DNA repair: a critical player in the response of cells of the CNS to genotoxic insults.

LeDoux SP, Druzhyna NM, Hollensworth SB, Harrison JF, Wilson GL. LeDoux SP, et al. Among authors: druzhyna nm. Neuroscience. 2007 Apr 14;145(4):1249-59. doi: 10.1016/j.neuroscience.2006.10.002. Epub 2006 Nov 13. Neuroscience. 2007. PMID: 17097236 Free PMC article. Review.

3

Targeting human 8-oxoguanine glycosylase to mitochondria of oligodendrocytes protects against menadione-induced oxidative stress.

Druzhyna NM, Hollensworth SB, Kelley MR, Wilson GL, Ledoux SP. Druzhyna NM, et al. Glia. 2003 Jun;42(4):370-8. doi: 10.1002/glia.10230. Glia. 2003. PMID: 12730957

4

Cytokines induce nitric oxide-mediated mtDNA damage and apoptosis in oligodendrocytes. Protective role of targeting 8-oxoguanine glycosylase to mitochondria.

Druzhyna NM, Musiyenko SI, Wilson GL, LeDoux SP. Druzhyna NM, et al. J Biol Chem. 2005 Jun 3;280(22):21673-9. doi: 10.1074/jbc.M411531200. Epub 2005 Apr 4. J Biol Chem. 2005. PMID: 15811855 Free article.

5

Mitochondrial DNA repair in aging and disease.

Druzhyna NM, Wilson GL, LeDoux SP. Druzhyna NM, et al. Mech Ageing Dev. 2008 Jul-Aug;129(7-8):383-90. doi: 10.1016/j.mad.2008.03.002. Epub 2008 Mar 13. Mech Ageing Dev. 2008. PMID: 18417187 Free PMC article. Review.

6

Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome.

Druzhyna N, Nair RG, LeDoux SP, Wilson GL. Druzhyna N, et al. Mutat Res. 1998 Nov 12;409(2):81-9. doi: 10.1016/s0921-8777(98)00042-1. Mutat Res. 1998. PMID: 9838924

7

Nitric oxide-induced damage to mtDNA and its subsequent repair.

Grishko VI, Druzhyna N, LeDoux SP, Wilson GL. Grishko VI, et al. Nucleic Acids Res. 1999 Nov 15;27(22):4510-6. doi: 10.1093/nar/27.22.4510. Nucleic Acids Res. 1999. PMID: 10536162 Free PMC article.

8

Poly(ADP-ribose) polymerase facilitates the repair of N-methylpurines in mitochondrial DNA.

Druzhyna N, Smulson ME, LeDoux SP, Wilson GL. Druzhyna N, et al. Diabetes. 2000 Nov;49(11):1849-55. doi: 10.2337/diabetes.49.11.1849. Diabetes. 2000. PMID: 11078451

9

Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics.

Szczesny B, Marcatti M, Zatarain JR, Druzhyna N, Wiktorowicz JE, Nagy P, Hellmich MR, Szabo C. Szczesny B, et al. Sci Rep. 2016 Nov 3;6:36125. doi: 10.1038/srep36125. Sci Rep. 2016. PMID: 27808278 Free PMC article.

10

Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer.

Druzhyna N, Szczesny B, Olah G, Módis K, Asimakopoulou A, Pavlidou A, Szoleczky P, Gerö D, Yanagi K, Törö G, López-García I, Myrianthopoulos V, Mikros E, Zatarain JR, Chao C, Papapetropoulos A, Hellmich MR, Szabo C. Druzhyna N, et al. Pharmacol Res. 2016 Nov;113(Pt A):18-37. doi: 10.1016/j.phrs.2016.08.016. Epub 2016 Aug 10. Pharmacol Res. 2016. PMID: 27521834 Free PMC article.

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