Wang L - Search Results

1

Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors.

Hasegawa M, Nishigaki N, Washio Y, Kano K, Harris PA, Sato H, Mori I, West RI, Shibahara M, Toyoda H, Wang L, Nolte RT, Veal JM, Cheung M. Hasegawa M, et al. Among authors: wang l. J Med Chem. 2007 Sep 6;50(18):4453-70. doi: 10.1021/jm0611051. Epub 2007 Aug 4. J Med Chem. 2007. PMID: 17676829

2

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Kim D, Wang L, Beconi M, Eiermann GJ, Fisher MH, He H, Hickey GJ, Kowalchick JE, Leiting B, Lyons K, Marsilio F, McCann ME, Patel RA, Petrov A, Scapin G, Patel SB, Roy RS, Wu JK, Wyvratt MJ, Zhang BB, Zhu L, Thornberry NA, Weber AE. Kim D, et al. Among authors: wang l. J Med Chem. 2005 Jan 13;48(1):141-51. doi: 10.1021/jm0493156. J Med Chem. 2005. PMID: 15634008

3

Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.

Harris PA, Cheung M, Hunter RN 3rd, Brown ML, Veal JM, Nolte RT, Wang L, Liu W, Crosby RM, Johnson JH, Epperly AH, Kumar R, Luttrell DK, Stafford JA. Harris PA, et al. Among authors: wang l. J Med Chem. 2005 Mar 10;48(5):1610-9. doi: 10.1021/jm049538w. J Med Chem. 2005. PMID: 15743202

4

Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors.

Miyazaki Y, Matsunaga S, Tang J, Maeda Y, Nakano M, Philippe RJ, Shibahara M, Liu W, Sato H, Wang L, Nolte RT. Miyazaki Y, et al. Among authors: wang l. Bioorg Med Chem Lett. 2005 May 2;15(9):2203-7. doi: 10.1016/j.bmcl.2005.03.034. Bioorg Med Chem Lett. 2005. PMID: 15837294

5

Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase.

Sammond DM, Nailor KE, Veal JM, Nolte RT, Wang L, Knick VB, Rudolph SK, Truesdale AT, Nartey EN, Stafford JA, Kumar R, Cheung M. Sammond DM, et al. Among authors: wang l. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3519-23. doi: 10.1016/j.bmcl.2005.05.096. Bioorg Med Chem Lett. 2005. PMID: 15990302

6

Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.

Chao EY, Collins JL, Gaillard S, Miller AB, Wang L, Orband-Miller LA, Nolte RT, McDonnell DP, Willson TM, Zuercher WJ. Chao EY, et al. Among authors: wang l. Bioorg Med Chem Lett. 2006 Feb 15;16(4):821-4. doi: 10.1016/j.bmcl.2005.11.030. Epub 2005 Nov 22. Bioorg Med Chem Lett. 2006. PMID: 16307879

7

X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.

Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT. Wang L, et al. J Biol Chem. 2006 Dec 8;281(49):37773-81. doi: 10.1074/jbc.M608410200. Epub 2006 Sep 21. J Biol Chem. 2006. PMID: 16990259 Free article.

8

Crystallization of protein-ligand complexes.

Hassell AM, An G, Bledsoe RK, Bynum JM, Carter HL 3rd, Deng SJ, Gampe RT, Grisard TE, Madauss KP, Nolte RT, Rocque WJ, Wang L, Weaver KL, Williams SP, Wisely GB, Xu R, Shewchuk LM. Hassell AM, et al. Among authors: wang l. Acta Crystallogr D Biol Crystallogr. 2007 Jan;63(Pt 1):72-9. doi: 10.1107/S0907444906047020. Epub 2006 Dec 13. Acta Crystallogr D Biol Crystallogr. 2007. PMID: 17164529 Free PMC article. Review.

9

Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2.

Miyazaki Y, Tang J, Maeda Y, Nakano M, Wang L, Nolte RT, Sato H, Sugai M, Okamoto Y, Truesdale AT, Hassler DF, Nartey EN, Patrick DR, Ho ML, Ozawa K. Miyazaki Y, et al. Among authors: wang l. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1773-8. doi: 10.1016/j.bmcl.2006.12.077. Epub 2006 Dec 24. Bioorg Med Chem Lett. 2007. PMID: 17276055

10

4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.

Duffy JL, Kirk BA, Wang L, Eiermann GJ, He H, Leiting B, Lyons KA, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE. Duffy JL, et al. Among authors: wang l. Bioorg Med Chem Lett. 2007 May 15;17(10):2879-85. doi: 10.1016/j.bmcl.2007.02.066. Epub 2007 Feb 25. Bioorg Med Chem Lett. 2007. PMID: 17350841

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