Scott MK - Search Results

1

2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.

Baxter EW, Conway KA, Kennis L, Bischoff F, Mercken MH, Winter HL, Reynolds CH, Tounge BA, Luo C, Scott MK, Huang Y, Braeken M, Pieters SM, Berthelot DJ, Masure S, Bruinzeel WD, Jordan AD, Parker MH, Boyd RE, Qu J, Alexander RS, Brenneman DE, Reitz AB. Baxter EW, et al. Among authors: scott mk. J Med Chem. 2007 Sep 6;50(18):4261-4. doi: 10.1021/jm0705408. Epub 2007 Aug 8. J Med Chem. 2007. PMID: 17685503

2

Synthesis of (-)-5,8-dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: an inhibitor of beta-amyloid(1-42) aggregation.

Parker MH, Chen R, Conway KA, Lee DH, Luo C, Boyd RE, Nortey SO, Ross TM, Scott MK, Reitz AB. Parker MH, et al. Among authors: scott mk. Bioorg Med Chem. 2002 Nov;10(11):3565-9. doi: 10.1016/s0968-0896(02)00251-1. Bioorg Med Chem. 2002. PMID: 12213471

3

2,3-Diaryl-5-anilino[1,2,4]thiadiazoles as melanocortin MC4 receptor agonists and their effects on feeding behavior in rats.

Pan K, Scott MK, Lee DH, Fitzpatrick LJ, Crooke JJ, Rivero RA, Rosenthal DI, Vaidya AH, Zhao B, Reitz AB. Pan K, et al. Among authors: scott mk. Bioorg Med Chem. 2003 Jan 17;11(2):185-92. doi: 10.1016/s0968-0896(02)00428-5. Bioorg Med Chem. 2003. PMID: 12470712

4

Piperazinylalkyl heterocycles as potential antipsychotic agents.

Scott MK, Baxter EW, Bennett DJ, Boyd RE, Blum PS, Codd EE, Kukla MJ, Malloy E, Maryanoff BE, Maryanoff CA, et al. Scott MK, et al. J Med Chem. 1995 Oct 13;38(21):4198-210. doi: 10.1021/jm00021a009. J Med Chem. 1995. PMID: 7473547

5

Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors.

Reitz AB, Baxter EW, Codd EE, Davis CB, Jordan AD, Maryanoff BE, Maryanoff CA, McDonnell ME, Powell ET, Renzi MJ, Schott MR, Scott MK, Shank RP, Vaught JL. Reitz AB, et al. Among authors: scott mk. J Med Chem. 1998 Jun 4;41(12):1997-2009. doi: 10.1021/jm970164z. J Med Chem. 1998. PMID: 9622541

6

2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor.

Scott MK, Ross TM, Lee DH, Wang HY, Shank RP, Wild KD, Davis CB, Crooke JJ, Potocki AC, Reitz AB. Scott MK, et al. Bioorg Med Chem. 2000 Jun;8(6):1383-91. doi: 10.1016/s0968-0896(00)00062-6. Bioorg Med Chem. 2000. PMID: 10896115

7

A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety.

Ross TM, Battista K, Bignan GC, Brenneman DE, Connolly PJ, Liu J, Middleton SA, Orsini M, Reitz AB, Rosenthal DI, Scott MK, Vaidya AH. Ross TM, et al. Among authors: scott mk. Bioorg Med Chem Lett. 2015 Feb 1;25(3):602-6. doi: 10.1016/j.bmcl.2014.12.015. Epub 2014 Dec 17. Bioorg Med Chem Lett. 2015. PMID: 25556095

8

A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.

Reitz AB, Bennett DJ, Blum PS, Codd EE, Maryanoff CA, Ortegon ME, Renzi MJ, Scott MK, Shank RP, Vaught JL. Reitz AB, et al. Among authors: scott mk. J Med Chem. 1994 Apr 15;37(8):1060-2. doi: 10.1021/jm00034a003. J Med Chem. 1994. PMID: 7909336 No abstract available.

9

New directions in anxiolytic drug research.

Scott MK, Demeter DA, Nortey SO, Dubinsky B, Shank RP, Reitz AB. Scott MK, et al. Prog Med Chem. 1999;36:169-200. doi: 10.1016/s0079-6468(08)70047-x. Prog Med Chem. 1999. PMID: 10818673 Review.

10

Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TIBO) derivatives.

Kukla MJ, Breslin HJ, Pauwels R, Fedde CL, Miranda M, Scott MK, Sherrill RG, Raeymaekers A, Van Gelder J, Andries K, et al. Kukla MJ, et al. Among authors: scott mk. J Med Chem. 1991 Feb;34(2):746-51. doi: 10.1021/jm00106a040. J Med Chem. 1991. PMID: 1995896

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