Chapman KT - Search Results

1

Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus.

Raghavan S, Lu Z, Beeson T, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Gabryelski L, Emini E, Tata JR. Raghavan S, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5432-6. doi: 10.1016/j.bmcl.2007.07.040. Epub 2007 Jul 31. Bioorg Med Chem Lett. 2007. PMID: 17692518

2

Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus.

Lu Z, Raghavan S, Bohn J, Charest M, Stahlhut MW, Rutkowski CA, Simcoe AL, Olsen DB, Schleif WA, Carella A, Gabryelski L, Jin L, Lin JH, Emini E, Chapman K, Tata JR. Lu Z, et al. Bioorg Med Chem Lett. 2003 May 19;13(10):1821-4. doi: 10.1016/s0960-894x(03)00262-2. Bioorg Med Chem Lett. 2003. PMID: 12729673

3

Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus.

Lu Z, Bohn J, Rano T, Rutkowski CA, Simcoe AL, Olsen DB, Schleif WA, Carella A, Gabryelski L, Jin L, Lin JH, Emini E, Chapman K, Tata JR. Lu Z, et al. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5311-4. doi: 10.1016/j.bmcl.2005.08.072. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16203148

4

A combinatorial library of indinavir analogues and its in vitro and in vivo studies.

Cheng Y, Rano TA, Huening TT, Zhang F, Lu Z, Schleif WA, Gabryelski L, Olsen DB, Stahlhut M, Kuo LC, Lin JH, Xu X, Jin L, Olah TV, McLoughlin DA, King RC, Chapman KT, Tata JR. Cheng Y, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2002 Feb 25;12(4):529-32. doi: 10.1016/s0960-894x(01)00824-1. Bioorg Med Chem Lett. 2002. PMID: 11844665

5

Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-resistant viral strains.

Cheng Y, Zhang F, Rano TA, Lu Z, Schleif WA, Gabryelski L, Olsen DB, Stahlhut M, Rutkowski CA, Lin JH, Jin L, Emini EA, Chapman KT, Tata JR. Cheng Y, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2419-22. doi: 10.1016/s0960-894x(02)00424-9. Bioorg Med Chem Lett. 2002. PMID: 12161147

6

Synthesis and activity of novel HIV protease inhibitors with improved potency against multiple PI-resistant viral strains.

Duffy JL, Kevin NJ, Kirk BA, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Duffy JL, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2423-6. doi: 10.1016/s0960-894x(02)00425-0. Bioorg Med Chem Lett. 2002. PMID: 12161148

7

Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2'.

Raghavan S, Yang Z, Mosley RT, Schleif WA, Gabryelski L, Olsen DB, Stahlhut M, Kuo LC, Emini EA, Chapman KT, Tata JR. Raghavan S, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2855-8. doi: 10.1016/s0960-894x(02)00632-7. Bioorg Med Chem Lett. 2002. PMID: 12270162

8

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.

Lynch CL, Hale JJ, Budhu RJ, Gentry AL, Mills SG, Chapman KT, MacCoss M, Malkowitz L, Springer MS, Gould SL, DeMartino JA, Siciliano SJ, Cascieri MA, Carella A, Carver G, Holmes K, Schleif WA, Danzeisen R, Hazuda D, Kessler J, Lineberger J, Miller M, Emini EA. Lynch CL, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2002 Oct 21;12(20):3001-4. doi: 10.1016/s0960-894x(02)00606-6. Bioorg Med Chem Lett. 2002. PMID: 12270193

9

HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent.

Duffy JL, Rano TA, Kevin NJ, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Duffy JL, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2569-72. doi: 10.1016/s0960-894x(03)00475-x. Bioorg Med Chem Lett. 2003. PMID: 12852968

10

The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains.

Zhang F, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Zhang F, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2573-6. doi: 10.1016/s0960-894x(03)00474-8. Bioorg Med Chem Lett. 2003. PMID: 12852969

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