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Page 1
An efficient and scalable one-pot double Michael addition-Dieckmann condensation for the synthesis of 4,4-disubstituted cyclohexane beta-keto esters.
DeGraffenreid MR, Bennett S, Caille S, Gonzalez-Lopez de Turiso F, Hungate RW, Julian LD, Kaizerman JA, McMinn DL, Rew Y, Sun D, Yan X, Powers JP. DeGraffenreid MR, et al. Among authors: julian ld. J Org Chem. 2007 Sep 14;72(19):7455-8. doi: 10.1021/jo071202h. Epub 2007 Aug 14. J Org Chem. 2007. PMID: 17696402
Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.
Julian LD, Wang Z, Bostick T, Caille S, Choi R, DeGraffenreid M, Di Y, He X, Hungate RW, Jaen JC, Liu J, Monshouwer M, McMinn D, Rew Y, Sudom A, Sun D, Tu H, Ursu S, Walker N, Yan X, Ye Q, Powers JP. Julian LD, et al. J Med Chem. 2008 Jul 10;51(13):3953-60. doi: 10.1021/jm800310g. Epub 2008 Jun 14. J Med Chem. 2008. PMID: 18553955
Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.
McMinn DL, Rew Y, Sudom A, Caille S, Degraffenreid M, He X, Hungate R, Jiang B, Jaen J, Julian LD, Kaizerman J, Novak P, Sun D, Tu H, Ursu S, Walker NP, Yan X, Ye Q, Wang Z, Powers JP. McMinn DL, et al. Among authors: julian ld. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1446-50. doi: 10.1016/j.bmcl.2009.01.026. Epub 2009 Jan 15. Bioorg Med Chem Lett. 2009. PMID: 19185488
Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors.
Sun D, Wang Z, Caille S, DeGraffenreid M, Gonzalez-Lopez de Turiso F, Hungate R, Jaen JC, Jiang B, Julian LD, Kelly R, McMinn DL, Kaizerman J, Rew Y, Sudom A, Tu H, Ursu S, Walker N, Willcockson M, Yan X, Ye Q, Powers JP. Sun D, et al. Among authors: julian ld. Bioorg Med Chem Lett. 2011 Jan 1;21(1):405-10. doi: 10.1016/j.bmcl.2010.10.129. Epub 2010 Oct 31. Bioorg Med Chem Lett. 2011. PMID: 21093258
Rational design and binding mode duality of MDM2-p53 inhibitors.
Gonzalez-Lopez de Turiso F, Sun D, Rew Y, Bartberger MD, Beck HP, Canon J, Chen A, Chow D, Correll TL, Huang X, Julian LD, Kayser F, Lo MC, Long AM, McMinn D, Oliner JD, Osgood T, Powers JP, Saiki AY, Schneider S, Shaffer P, Xiao SH, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Medina JC, Olson SH. Gonzalez-Lopez de Turiso F, et al. Among authors: julian ld. J Med Chem. 2013 May 23;56(10):4053-70. doi: 10.1021/jm400293z. Epub 2013 May 6. J Med Chem. 2013. PMID: 23597064
Total synthesis of (+)-13-deoxytedanolide.
Julian LD, Newcom JS, Roush WR. Julian LD, et al. J Am Chem Soc. 2005 May 4;127(17):6186-7. doi: 10.1021/ja050729d. J Am Chem Soc. 2005. PMID: 15853320
One-year clinical experience of perampanel in Spain: a multicentre study of efficacy and tolerability.
Garamendi-Ruiz I, García-García ME, Bertol-Alegre V, Mauri-Llerda JÁ, García-Morales I, Garayoa-Irigoyen V, Agúndez-Sarasola M, De Toledo-Heras M, García-Morales V, García-Gomara MJ, Arcos-Sánchez C, Gago-Veiga A, Escalza-Cortina I, Rueda-Mena E, Muñoz-Fargas E, Santos-Lasaosa S, Oliván-Usieto JA, Julián LD, Gómez-Esteban JC, Marinas-Alejo A. Garamendi-Ruiz I, et al. Among authors: julian ld. Epileptic Disord. 2016 Jun 1;18(2):173-80. doi: 10.1684/epd.2016.0824. Epileptic Disord. 2016. PMID: 27238234