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4-nitroacetophenone-derived thiosemicarbazones and their copper(II) complexes with significant in vitro anti-trypanosomal activity.
Pérez-Rebolledo A, Teixeira LR, Batista AA, Mangrich AS, Aguirre G, Cerecetto H, González M, Hernández P, Ferreira AM, Speziali NL, Beraldo H. Pérez-Rebolledo A, et al. Among authors: aguirre g. Eur J Med Chem. 2008 May;43(5):939-48. doi: 10.1016/j.ejmech.2007.06.020. Epub 2007 Jul 10. Eur J Med Chem. 2008. PMID: 17709156
Design, synthesis and biological evaluation of new potent 5-nitrofuryl derivatives as anti-Trypanosoma cruzi agents. Studies of trypanothione binding site of trypanothione reductase as target for rational design.
Aguirre G, Cabrera E, Cerecetto H, Di Maio R, González M, Seoane G, Duffaut A, Denicola A, Gil MJ, Martínez-Merino V. Aguirre G, et al. Eur J Med Chem. 2004 May;39(5):421-31. doi: 10.1016/j.ejmech.2004.02.007. Eur J Med Chem. 2004. PMID: 15110968
Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure-activity relationships.
Porcal W, Hernández P, Aguirre G, Boiani L, Boiani M, Merlino A, Ferreira A, Maio RD, Castro A, González M, Cerecetto H. Porcal W, et al. Among authors: aguirre g. Bioorg Med Chem. 2007 Apr 1;15(7):2768-81. doi: 10.1016/j.bmc.2007.01.009. Epub 2007 Jan 12. Bioorg Med Chem. 2007. PMID: 17287123
In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives.
Porcal W, Hernández P, Boiani M, Aguirre G, Boiani L, Chidichimo A, Cazzulo JJ, Campillo NE, Paez JA, Castro A, Krauth-Siegel RL, Davies C, Basombrío MA, González M, Cerecetto H. Porcal W, et al. Among authors: aguirre g. J Med Chem. 2007 Nov 29;50(24):6004-15. doi: 10.1021/jm070604e. Epub 2007 Oct 26. J Med Chem. 2007. PMID: 17960923
615 results