Spencer J - Search Results

1

Structural basis for the role of Asp-120 in metallo-beta-lactamases.

Crisp J, Conners R, Garrity JD, Carenbauer AL, Crowder MW, Spencer J. Crisp J, et al. Among authors: spencer j. Biochemistry. 2007 Sep 18;46(37):10664-74. doi: 10.1021/bi700707u. Epub 2007 Aug 23. Biochemistry. 2007. PMID: 17715946

2

Domain behavior during the folding of a thermostable phosphoglycerate kinase.

Parker MJ, Spencer J, Jackson GS, Burston SG, Hosszu LL, Craven CJ, Waltho JP, Clarke AR. Parker MJ, et al. Among authors: spencer j. Biochemistry. 1996 Dec 10;35(49):15740-52. doi: 10.1021/bi961330s. Biochemistry. 1996. PMID: 8961937

3

Overexpression, purification, and characterization of the cloned metallo-beta-lactamase L1 from Stenotrophomonas maltophilia.

Crowder MW, Walsh TR, Banovic L, Pettit M, Spencer J. Crowder MW, et al. Among authors: spencer j. Antimicrob Agents Chemother. 1998 Apr;42(4):921-6. doi: 10.1128/AAC.42.4.921. Antimicrob Agents Chemother. 1998. PMID: 9559809 Free PMC article.

4

Novel mechanism of hydrolysis of therapeutic beta-lactams by Stenotrophomonas maltophilia L1 metallo-beta-lactamase.

Spencer J, Clarke AR, Walsh TR. Spencer J, et al. J Biol Chem. 2001 Sep 7;276(36):33638-44. doi: 10.1074/jbc.M105550200. Epub 2001 Jul 6. J Biol Chem. 2001. PMID: 11443136 Free article.

5

Over-expression, purification, and characterization of metallo-beta-lactamase ImiS from Aeromonas veronii bv. sobria.

Crawford PA, Sharma N, Chandrasekar S, Sigdel T, Walsh TR, Spencer J, Crowder MW. Crawford PA, et al. Among authors: spencer j. Protein Expr Purif. 2004 Aug;36(2):272-9. doi: 10.1016/j.pep.2004.04.017. Protein Expr Purif. 2004. PMID: 15249050

6

Antibiotic recognition by binuclear metallo-beta-lactamases revealed by X-ray crystallography.

Spencer J, Read J, Sessions RB, Howell S, Blackburn GM, Gamblin SJ. Spencer J, et al. J Am Chem Soc. 2005 Oct 19;127(41):14439-44. doi: 10.1021/ja0536062. J Am Chem Soc. 2005. PMID: 16218639

7

A new approach to the inhibition of metallo-beta-lactamases.

Spencer J, Walsh TR. Spencer J, et al. Angew Chem Int Ed Engl. 2006 Feb 6;45(7):1022-6. doi: 10.1002/anie.200502984. Angew Chem Int Ed Engl. 2006. PMID: 16404761 Review. No abstract available.

8

Crystal structure of Pseudomonas aeruginosa SPM-1 provides insights into variable zinc affinity of metallo-beta-lactamases.

Murphy TA, Catto LE, Halford SE, Hadfield AT, Minor W, Walsh TR, Spencer J. Murphy TA, et al. Among authors: spencer j. J Mol Biol. 2006 Mar 31;357(3):890-903. doi: 10.1016/j.jmb.2006.01.003. Epub 2006 Jan 23. J Mol Biol. 2006. PMID: 16460758

9

Metallo-beta-lactamases: novel weaponry for antibiotic resistance in bacteria.

Crowder MW, Spencer J, Vila AJ. Crowder MW, et al. Among authors: spencer j. Acc Chem Res. 2006 Oct;39(10):721-8. doi: 10.1021/ar0400241. Acc Chem Res. 2006. PMID: 17042472 Review.

10

Crystal structure of the LasA virulence factor from Pseudomonas aeruginosa: substrate specificity and mechanism of M23 metallopeptidases.

Spencer J, Murphy LM, Conners R, Sessions RB, Gamblin SJ. Spencer J, et al. J Mol Biol. 2010 Mar 5;396(4):908-23. doi: 10.1016/j.jmb.2009.12.021. Epub 2009 Dec 21. J Mol Biol. 2010. PMID: 20026068

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