Purushothaman A - Search Results

1

Antibody GD3G7 selected against embryonic glycosaminoglycans defines chondroitin sulfate-E domains highly up-regulated in ovarian cancer and involved in vascular endothelial growth factor binding.

ten Dam GB, van de Westerlo EM, Purushothaman A, Stan RV, Bulten J, Sweep FC, Massuger LF, Sugahara K, van Kuppevelt TH. ten Dam GB, et al. Among authors: purushothaman a. Am J Pathol. 2007 Oct;171(4):1324-33. doi: 10.2353/ajpath.2007.070111. Epub 2007 Aug 23. Am J Pathol. 2007. PMID: 17717144 Free PMC article.

2

Functions of chondroitin sulfate/dermatan sulfate chains in brain development. Critical roles of E and iE disaccharide units recognized by a single chain antibody GD3G7.

Purushothaman A, Fukuda J, Mizumoto S, ten Dam GB, van Kuppevelt TH, Kitagawa H, Mikami T, Sugahara K. Purushothaman A, et al. J Biol Chem. 2007 Jul 6;282(27):19442-52. doi: 10.1074/jbc.M700630200. Epub 2007 May 10. J Biol Chem. 2007. PMID: 17500059 Free article.

3

Dermatan sulfate domains defined by the novel antibody GD3A12, in normal tissues and ovarian adenocarcinomas.

Ten Dam GB, Yamada S, Kobayashi F, Purushothaman A, van de Westerlo EM, Bulten J, Malmström A, Sugahara K, Massuger LF, van Kuppevelt TH. Ten Dam GB, et al. Among authors: purushothaman a. Histochem Cell Biol. 2009 Jul;132(1):117-27. doi: 10.1007/s00418-009-0592-2. Epub 2009 Apr 10. Histochem Cell Biol. 2009. PMID: 19360434

4

Chondroitin sulfate "wobble motifs" modulate maintenance and differentiation of neural stem cells and their progeny.

Purushothaman A, Sugahara K, Faissner A. Purushothaman A, et al. J Biol Chem. 2012 Jan 27;287(5):2935-42. doi: 10.1074/jbc.R111.298430. Epub 2011 Nov 17. J Biol Chem. 2012. PMID: 22094467 Free PMC article. Review.

5

A small oxazine compound as an anti-tumor agent: a novel pyranoside mimetic that binds to VEGF, HB-EGF, and TNF-α.

Basappa, Murugan S, Kavitha CV, Purushothaman A, Nevin KG, Sugahara K, Rangappa KS. Basappa, et al. Among authors: purushothaman a. Cancer Lett. 2010 Nov 28;297(2):231-43. doi: 10.1016/j.canlet.2010.05.016. Epub 2010 Jun 17. Cancer Lett. 2010. PMID: 20831981 Free article.

6

Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype.

Purushothaman A, Hurst DR, Pisano C, Mizumoto S, Sugahara K, Sanderson RD. Purushothaman A, et al. J Biol Chem. 2011 Sep 2;286(35):30377-30383. doi: 10.1074/jbc.M111.254789. Epub 2011 Jul 11. J Biol Chem. 2011. PMID: 21757697 Free PMC article.

7

Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis.

Purushothaman A, Uyama T, Kobayashi F, Yamada S, Sugahara K, Rapraeger AC, Sanderson RD. Purushothaman A, et al. Blood. 2010 Mar 25;115(12):2449-57. doi: 10.1182/blood-2009-07-234757. Epub 2010 Jan 22. Blood. 2010. PMID: 20097882 Free PMC article.

8

Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.

Yoshida CA, Kawane T, Moriishi T, Purushothaman A, Miyazaki T, Komori H, Mori M, Qin X, Hashimoto A, Sugahara K, Yamana K, Takada K, Komori T. Yoshida CA, et al. Among authors: purushothaman a. J Biol Chem. 2014 Sep 19;289(38):26584-26596. doi: 10.1074/jbc.M114.555987. Epub 2014 Aug 8. J Biol Chem. 2014. PMID: 25107907 Free PMC article.

9

Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatins.

Jung O, Trapp-Stamborski V, Purushothaman A, Jin H, Wang H, Sanderson RD, Rapraeger AC. Jung O, et al. Among authors: purushothaman a. Oncogenesis. 2016 Feb 29;5(2):e202. doi: 10.1038/oncsis.2016.5. Oncogenesis. 2016. PMID: 26926788 Free PMC article.

10

Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma.

Purushothaman A, Babitz SK, Sanderson RD. Purushothaman A, et al. J Biol Chem. 2012 Nov 30;287(49):41288-96. doi: 10.1074/jbc.M112.391417. Epub 2012 Oct 9. J Biol Chem. 2012. PMID: 23048032 Free PMC article.

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