Downward J - Search Results

1

Initiation of high frequency multi-drug resistance following kinase targeting by siRNAs.

Swanton C, Nicke B, Marani M, Kelly G, Downward J. Swanton C, et al. Among authors: downward j. Cell Cycle. 2007 Aug 15;6(16):2001-4. doi: 10.4161/cc.6.16.4538. Epub 2007 Jun 4. Cell Cycle. 2007. PMID: 17721083

2

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.

Marani M, Tenev T, Hancock D, Downward J, Lemoine NR. Marani M, et al. Among authors: downward j. Mol Cell Biol. 2002 Jun;22(11):3577-89. doi: 10.1128/MCB.22.11.3577-3589.2002. Mol Cell Biol. 2002. PMID: 11997495 Free PMC article.

3

Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma.

Agathanggelou A, Bièche I, Ahmed-Choudhury J, Nicke B, Dammann R, Baksh S, Gao B, Minna JD, Downward J, Maher ER, Latif F. Agathanggelou A, et al. Among authors: downward j. Cancer Res. 2003 Sep 1;63(17):5344-51. Cancer Res. 2003. PMID: 14500366 Free PMC article.

4

Role of Bim in the survival pathway induced by Raf in epithelial cells.

Marani M, Hancock D, Lopes R, Tenev T, Downward J, Lemoine NR. Marani M, et al. Among authors: downward j. Oncogene. 2004 Apr 1;23(14):2431-41. doi: 10.1038/sj.onc.1207364. Oncogene. 2004. PMID: 14676826

5

The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component.

Schulze A, Nicke B, Warne PH, Tomlinson S, Downward J. Schulze A, et al. Among authors: downward j. Mol Biol Cell. 2004 Jul;15(7):3450-63. doi: 10.1091/mbc.e03-11-0807. Epub 2004 Apr 16. Mol Biol Cell. 2004. PMID: 15090615 Free PMC article.

6

RNA interference, DNA methylation, and gene silencing: a bright future for cancer therapy?

Swanton C, Nicke B, Downward J. Swanton C, et al. Among authors: downward j. Lancet Oncol. 2004 Nov;5(11):653-4. doi: 10.1016/S1470-2045(04)01604-3. Lancet Oncol. 2004. PMID: 15522650 No abstract available.

7

Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.

Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, Hancock DC. Nicke B, et al. Among authors: downward j. Mol Cell. 2005 Dec 9;20(5):673-85. doi: 10.1016/j.molcel.2005.10.038. Mol Cell. 2005. PMID: 16337592 Free article.

8

Chromosomal instability, colorectal cancer and taxane resistance.

Swanton C, Tomlinson I, Downward J. Swanton C, et al. Among authors: downward j. Cell Cycle. 2006 Apr;5(8):818-23. doi: 10.4161/cc.5.8.2682. Epub 2006 Apr 17. Cell Cycle. 2006. PMID: 16628000 Review.

9

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.

Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J. Gupta S, et al. Among authors: downward j. Cell. 2007 Jun 1;129(5):957-68. doi: 10.1016/j.cell.2007.03.051. Cell. 2007. PMID: 17540175 Free article.

10

Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.

Swanton C, Marani M, Pardo O, Warne PH, Kelly G, Sahai E, Elustondo F, Chang J, Temple J, Ahmed AA, Brenton JD, Downward J, Nicke B. Swanton C, et al. Among authors: downward j. Cancer Cell. 2007 Jun;11(6):498-512. doi: 10.1016/j.ccr.2007.04.011. Cancer Cell. 2007. PMID: 17560332 Free article.

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