Hymowitz SG - Search Results

1

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.

Wagner KW, Punnoose EA, Januario T, Lawrence DA, Pitti RM, Lancaster K, Lee D, von Goetz M, Yee SF, Totpal K, Huw L, Katta V, Cavet G, Hymowitz SG, Amler L, Ashkenazi A. Wagner KW, et al. Among authors: hymowitz sg. Nat Med. 2007 Sep;13(9):1070-7. doi: 10.1038/nm1627. Epub 2007 Sep 2. Nat Med. 2007. PMID: 17767167

2

Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.

Hymowitz SG, Christinger HW, Fuh G, Ultsch M, O'Connell M, Kelley RF, Ashkenazi A, de Vos AM. Hymowitz SG, et al. Mol Cell. 1999 Oct;4(4):563-71. doi: 10.1016/s1097-2765(00)80207-5. Mol Cell. 1999. PMID: 10549288 Free article.

3

A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL.

Hymowitz SG, O'Connell MP, Ultsch MH, Hurst A, Totpal K, Ashkenazi A, de Vos AM, Kelley RF. Hymowitz SG, et al. Biochemistry. 2000 Feb 1;39(4):633-40. doi: 10.1021/bi992242l. Biochemistry. 2000. PMID: 10651627

4

Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling.

Kelley RF, Totpal K, Lindstrom SH, Mathieu M, Billeci K, Deforge L, Pai R, Hymowitz SG, Ashkenazi A. Kelley RF, et al. Among authors: hymowitz sg. J Biol Chem. 2005 Jan 21;280(3):2205-12. doi: 10.1074/jbc.M410660200. Epub 2004 Nov 1. J Biol Chem. 2005. PMID: 15520016 Free article.

5

Toward small-molecule agonists of TNF receptors.

Hymowitz SG, Ashkenazi A. Hymowitz SG, et al. Nat Chem Biol. 2005 Dec;1(7):353-4. doi: 10.1038/nchembio1205-353. Nat Chem Biol. 2005. PMID: 16370368 No abstract available.

6

Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists.

Li B, Russell SJ, Compaan DM, Totpal K, Marsters SA, Ashkenazi A, Cochran AG, Hymowitz SG, Sidhu SS. Li B, et al. Among authors: hymowitz sg. J Mol Biol. 2006 Aug 18;361(3):522-36. doi: 10.1016/j.jmb.2006.06.042. Epub 2006 Jul 7. J Mol Biol. 2006. PMID: 16859704

7

Delineation of the cell-extrinsic apoptosis pathway in the zebrafish.

Eimon PM, Kratz E, Varfolomeev E, Hymowitz SG, Stern H, Zha J, Ashkenazi A. Eimon PM, et al. Among authors: hymowitz sg. Cell Death Differ. 2006 Oct;13(10):1619-30. doi: 10.1038/sj.cdd.4402015. Epub 2006 Aug 4. Cell Death Differ. 2006. PMID: 16888647

8

Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5.

Adams C, Totpal K, Lawrence D, Marsters S, Pitti R, Yee S, Ross S, Deforge L, Koeppen H, Sagolla M, Compaan D, Lowman H, Hymowitz S, Ashkenazi A. Adams C, et al. Cell Death Differ. 2008 Apr;15(4):751-61. doi: 10.1038/sj.cdd.4402306. Epub 2008 Jan 25. Cell Death Differ. 2008. PMID: 18219321

9

Therapeutic antibody targeting of individual Notch receptors.

Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Zha J, Callahan CA, Hymowitz SG, Siebel CW. Wu Y, et al. Among authors: hymowitz sg. Nature. 2010 Apr 15;464(7291):1052-7. doi: 10.1038/nature08878. Nature. 2010. PMID: 20393564

10

An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells.

Wilson NS, Yang B, Yang A, Loeser S, Marsters S, Lawrence D, Li Y, Pitti R, Totpal K, Yee S, Ross S, Vernes JM, Lu Y, Adams C, Offringa R, Kelley B, Hymowitz S, Daniel D, Meng G, Ashkenazi A. Wilson NS, et al. Cancer Cell. 2011 Jan 18;19(1):101-13. doi: 10.1016/j.ccr.2010.11.012. Cancer Cell. 2011. PMID: 21251615 Free article.

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