Graham IR - Search Results

1

Comparative analysis of antisense oligonucleotide sequences for targeted skipping of exon 51 during dystrophin pre-mRNA splicing in human muscle.

Arechavala-Gomeza V, Graham IR, Popplewell LJ, Adams AM, Aartsma-Rus A, Kinali M, Morgan JE, van Deutekom JC, Wilton SD, Dickson G, Muntoni F. Arechavala-Gomeza V, et al. Among authors: graham ir. Hum Gene Ther. 2007 Sep;18(9):798-810. doi: 10.1089/hum.2006.061. Hum Gene Ther. 2007. PMID: 17767400 Free article.

2

Adenovirus-based targeting in myoblasts is hampered by nonhomologous vector integration.

Isman O, Roberts ML, Morgan JE, Graham IR, Goldring K, Lawrence-Watt DJ, Lu QL, Dunckley MG, Porter AC, Partridge TA, Dickson G. Isman O, et al. Among authors: graham ir. Hum Gene Ther. 2008 Oct;19(10):1000-8. doi: 10.1089/hum.2008.063. Hum Gene Ther. 2008. PMID: 18788904

3

Design of phosphorodiamidate morpholino oligomers (PMOs) for the induction of exon skipping of the human DMD gene.

Popplewell LJ, Trollet C, Dickson G, Graham IR. Popplewell LJ, et al. Among authors: graham ir. Mol Ther. 2009 Mar;17(3):554-61. doi: 10.1038/mt.2008.287. Epub 2009 Jan 13. Mol Ther. 2009. PMID: 19142179 Free PMC article.

4

Dosing regimen has a significant impact on the efficiency of morpholino oligomer-induced exon skipping in mdx mice.

Malerba A, Thorogood FC, Dickson G, Graham IR. Malerba A, et al. Among authors: graham ir. Hum Gene Ther. 2009 Sep;20(9):955-65. doi: 10.1089/hum.2008.157. Hum Gene Ther. 2009. PMID: 19469709

5

Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials.

Popplewell LJ, Adkin C, Arechavala-Gomeza V, Aartsma-Rus A, de Winter CL, Wilton SD, Morgan JE, Muntoni F, Graham IR, Dickson G. Popplewell LJ, et al. Among authors: graham ir. Neuromuscul Disord. 2010 Feb;20(2):102-10. doi: 10.1016/j.nmd.2009.10.013. Epub 2010 Jan 15. Neuromuscul Disord. 2010. PMID: 20079639

6

Screening for antisense modulation of dystrophin pre-mRNA splicing.

Dickson G, Hill V, Graham IR. Dickson G, et al. Among authors: graham ir. Neuromuscul Disord. 2002 Oct;12 Suppl 1:S67-70. doi: 10.1016/s0960-8966(02)00085-8. Neuromuscul Disord. 2002. PMID: 12206799 Review.

7

Towards a therapeutic inhibition of dystrophin exon 23 splicing in mdx mouse muscle induced by antisense oligoribonucleotides (splicomers): target sequence optimisation using oligonucleotide arrays.

Graham IR, Hill VJ, Manoharan M, Inamati GB, Dickson G. Graham IR, et al. J Gene Med. 2004 Oct;6(10):1149-58. doi: 10.1002/jgm.603. J Gene Med. 2004. PMID: 15386737

8

Human apolipoprotein E expression from mouse skeletal muscle by electrotransfer of nonviral DNA (plasmid) and pseudotyped recombinant adeno-associated virus (AAV2/7).

Evans V, Foster H, Graham IR, Foster K, Athanasopoulos T, Simons JP, Dickson G, Owen JS. Evans V, et al. Among authors: graham ir. Hum Gene Ther. 2008 Jun;19(6):569-78. doi: 10.1089/hum.2007.169. Hum Gene Ther. 2008. PMID: 18578629

9

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study.

Kinali M, Arechavala-Gomeza V, Feng L, Cirak S, Hunt D, Adkin C, Guglieri M, Ashton E, Abbs S, Nihoyannopoulos P, Garralda ME, Rutherford M, McCulley C, Popplewell L, Graham IR, Dickson G, Wood MJ, Wells DJ, Wilton SD, Kole R, Straub V, Bushby K, Sewry C, Morgan JE, Muntoni F. Kinali M, et al. Among authors: graham ir. Lancet Neurol. 2009 Oct;8(10):918-28. doi: 10.1016/S1474-4422(09)70211-X. Epub 2009 Aug 25. Lancet Neurol. 2009. PMID: 19713152 Free PMC article. Clinical Trial.

10

Chronic systemic therapy with low-dose morpholino oligomers ameliorates the pathology and normalizes locomotor behavior in mdx mice.

Malerba A, Sharp PS, Graham IR, Arechavala-Gomeza V, Foster K, Muntoni F, Wells DJ, Dickson G. Malerba A, et al. Among authors: graham ir. Mol Ther. 2011 Feb;19(2):345-54. doi: 10.1038/mt.2010.261. Epub 2010 Nov 23. Mol Ther. 2011. PMID: 21102560 Free PMC article.

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