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DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Millar JK, Pickard BS, Mackie S, James R, Christie S, Buchanan SR, Malloy MP, Chubb JE, Huston E, Baillie GS, Thomson PA, Hill EV, Brandon NJ, Rain JC, Camargo LM, Whiting PJ, Houslay MD, Blackwood DH, Muir WJ, Porteous DJ. Millar JK, et al. Among authors: muir wj. Science. 2005 Nov 18;310(5751):1187-91. doi: 10.1126/science.1112915. Science. 2005. PMID: 16293762
The PDE4B gene confers sex-specific protection against schizophrenia.
Pickard BS, Thomson PA, Christoforou A, Evans KL, Morris SW, Porteous DJ, Blackwood DH, Muir WJ. Pickard BS, et al. Among authors: muir wj. Psychiatr Genet. 2007 Jun;17(3):129-33. doi: 10.1097/YPG.0b013e328014492b. Psychiatr Genet. 2007. PMID: 17417055
Disrupted-in-Schizophrenia-1.
Muir WJ, Pickard BS, Blackwood DH. Muir WJ, et al. Curr Psychiatry Rep. 2008 Apr;10(2):140-7. doi: 10.1007/s11920-008-0025-2. Curr Psychiatry Rep. 2008. PMID: 18474207 Review.
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.
Eykelenboom JE, Briggs GJ, Bradshaw NJ, Soares DC, Ogawa F, Christie S, Malavasi EL, Makedonopoulou P, Mackie S, Malloy MP, Wear MA, Blackburn EA, Bramham J, McIntosh AM, Blackwood DH, Muir WJ, Porteous DJ, Millar JK. Eykelenboom JE, et al. Among authors: muir wj. Hum Mol Genet. 2012 Aug 1;21(15):3374-86. doi: 10.1093/hmg/dds169. Epub 2012 Apr 30. Hum Mol Genet. 2012. PMID: 22547224 Free PMC article.
Cytogenetics and gene discovery in psychiatric disorders.
Pickard BS, Millar JK, Porteous DJ, Muir WJ, Blackwood DH. Pickard BS, et al. Among authors: muir wj. Pharmacogenomics J. 2005;5(2):81-8. doi: 10.1038/sj.tpj.6500293. Pharmacogenomics J. 2005. PMID: 15668732 Review.
169 results