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From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.
Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG, Hunt SF, Ince F, Ingall AH, Kirk IP, Leeson PD, Leff P, Lewis RJ, Martin BP, McGinnity DF, Mortimore MP, Paine SW, Pairaudeau G, Patel A, Rigby AJ, Riley RJ, Teobald BJ, Tomlinson W, Webborn PJ, Willis PA. Springthorpe B, et al. Among authors: mortimore mp. Bioorg Med Chem Lett. 2007 Nov 1;17(21):6013-8. doi: 10.1016/j.bmcl.2007.07.057. Epub 2007 Aug 19. Bioorg Med Chem Lett. 2007. PMID: 17827008
The medicinal chemistry of the P2 receptor family.
Guile SD, Ince F, Ingall AH, Kindon ND, Meghani P, Mortimore MP. Guile SD, et al. Among authors: mortimore mp. Prog Med Chem. 2001;38:115-87. doi: 10.1016/s0079-6468(08)70093-6. Prog Med Chem. 2001. PMID: 11774794 Review. No abstract available.