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Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice.
Reddy LH, Khoury H, Paci A, Deroussent A, Ferreira H, Dubernet C, Declèves X, Besnard M, Chacun H, Lepêtre-Mouelhi S, Desmaële D, Rousseau B, Laugier C, Cintrat JC, Vassal G, Couvreur P. Reddy LH, et al. Among authors: couvreur p. Drug Metab Dispos. 2008 Aug;36(8):1570-7. doi: 10.1124/dmd.108.020735. Epub 2008 May 12. Drug Metab Dispos. 2008. PMID: 18474674
Simultaneous quantification of preactivated ifosfamide derivatives and of 4-hydroxyifosfamide by high performance liquid chromatography-tandem mass spectrometry in mouse plasma and its application to a pharmacokinetic study.
Deroussent A, Skarbek C, Maury A, Chapuis H, Daudigeos-Dubus E, Le Dret L, Durand S, Couvreur P, Desmaële D, Paci A. Deroussent A, et al. Among authors: couvreur p. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jun 15;992:30-5. doi: 10.1016/j.jchromb.2015.04.025. Epub 2015 Apr 20. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 25939095
Novel approaches to deliver gemcitabine to cancers.
Reddy LH, Couvreur P. Reddy LH, et al. Among authors: couvreur p. Curr Pharm Des. 2008;14(11):1124-37. doi: 10.2174/138161208784246216. Curr Pharm Des. 2008. PMID: 18473859 Review.
470 results