Chan TM - Search Results

1

Heterotricyclic himbacine analogs as potent, orally active thrombin receptor (protease activated receptor-1) antagonists.

Chelliah MV, Chackalamannil S, Xia Y, Eagen K, Clasby MC, Gao X, Greenlee W, Ahn HS, Agans-Fantuzzi J, Boykow G, Hsieh Y, Bryant M, Palamanda J, Chan TM, Hesk D, Chintala M. Chelliah MV, et al. Among authors: chan tm. J Med Chem. 2007 Oct 18;50(21):5147-60. doi: 10.1021/jm070704k. Epub 2007 Sep 14. J Med Chem. 2007. PMID: 17854166

2

Himbacine derived thrombin receptor (PAR-1) antagonists: structure-activity relationship of the lactone ring.

Xia Y, Chackalamannil S, Chan TM, Czarniecki M, Doller D, Eagen K, Greenlee WJ, Tsai H, Wang Y, Ahn HS, Boykow GC, McPhail AT. Xia Y, et al. Among authors: chan tm. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4969-72. doi: 10.1016/j.bmcl.2006.06.042. Epub 2006 Jul 7. Bioorg Med Chem Lett. 2006. PMID: 16824760

3

Discovery of nor-seco himbacine analogs as thrombin receptor antagonists.

Chelliah MV, Chackalamannil S, Xia Y, Eagen K, Greenlee WJ, Ahn HS, Agans-Fantuzzi J, Boykow G, Hsieh Y, Bryant M, Chan TM, Chintala M. Chelliah MV, et al. Among authors: chan tm. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2544-9. doi: 10.1016/j.bmcl.2012.01.138. Epub 2012 Feb 16. Bioorg Med Chem Lett. 2012. PMID: 22405832

4

Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.

Yang SW, Smotryski J, McElroy WT, Tan Z, Ho G, Tulshian D, Greenlee WJ, Guzzi M, Zhang X, Mullins D, Xiao L, Hruza A, Chan TM, Rindgen D, Bleickardt C, Hodgson R. Yang SW, et al. Among authors: chan tm. Bioorg Med Chem Lett. 2012 Jan 1;22(1):235-9. doi: 10.1016/j.bmcl.2011.11.023. Epub 2011 Nov 16. Bioorg Med Chem Lett. 2012. PMID: 22142545

5

A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors.

Wu WL, Sasikumar TK, Domalski MS, Qiang L, Burnett DA, Clader J, Greenlee WJ, Chan TM, Lee J, Zhang L. Wu WL, et al. Among authors: chan tm. Bioorg Med Chem Lett. 2013 Feb 1;23(3):850-3. doi: 10.1016/j.bmcl.2012.11.054. Epub 2012 Nov 28. Bioorg Med Chem Lett. 2013. PMID: 23265902

6

Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine.

Kaminski JJ, Carruthers NI, Wong SC, Chan TM, Billah MM, Tozzi S, McPhail AT. Kaminski JJ, et al. Among authors: chan tm. Bioorg Med Chem. 1999 Jul;7(7):1413-23. doi: 10.1016/s0968-0896(99)00075-9. Bioorg Med Chem. 1999. PMID: 10465415

7

Semi-synthetic aristolactams--inhibitors of CDK2 enzyme.

Hegde VR, Borges S, Pu H, Patel M, Gullo VP, Wu B, Kirschmeier P, Williams MJ, Madison V, Fischmann T, Chan TM. Hegde VR, et al. Among authors: chan tm. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1384-7. doi: 10.1016/j.bmcl.2010.01.007. Epub 2010 Jan 7. Bioorg Med Chem Lett. 2010. PMID: 20097066

8

Substituted 2-azaspiro[5.3]nonan-1-ones as potent cholesterol absorption inhibitors: defining a binding conformation for SCH 48461.

Dugar S, Clader JW, Chan TM, Davis H Jr. Dugar S, et al. Among authors: chan tm. J Med Chem. 1995 Dec 8;38(25):4875-7. doi: 10.1021/jm00025a002. J Med Chem. 1995. PMID: 8523398 No abstract available.

9

Chemical modifications and structure activity studies of ziracin and related everninomicin antibiotics.

Ganguly AK, McCormick JL, Saksena AK, Das PR, Chan TM. Ganguly AK, et al. Among authors: chan tm. Bioorg Med Chem Lett. 1999 Apr 19;9(8):1209-14. doi: 10.1016/s0960-894x(99)00163-8. Bioorg Med Chem Lett. 1999. PMID: 10328315

10

New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme.

Hegde VR, Borges S, Patel M, Das PR, Wu B, Gullo VP, Chan TM. Hegde VR, et al. Among authors: chan tm. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1344-6. doi: 10.1016/j.bmcl.2010.01.018. Epub 2010 Jan 11. Bioorg Med Chem Lett. 2010. PMID: 20097074

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