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Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.
Mol Cell Biol. 2007 Nov;27(22):8003-14. doi: 10.1128/MCB.00057-07. Epub 2007 Sep 17.
Mol Cell Biol. 2007.
PMID: 17875936
Free PMC article.
Structure-activity relationships of synthetic analogs of (-)-epigallocatechin-3-gallate as proteasome inhibitors.
Kazi A, Wang Z, Kumar N, Falsetti SC, Chan TH, Dou QP.
Kazi A, et al. Among authors: falsetti sc.
Anticancer Res. 2004 Mar-Apr;24(2B):943-54.
Anticancer Res. 2004.
PMID: 15161048
Free article.
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Anti-tumor activity of N-thiolated beta-lactam antibiotics.
Chen D, Falsetti SC, Frezza M, Milacic V, Kazi A, Cui QC, Long TE, Turos E, Dou QP.
Chen D, et al. Among authors: falsetti sc.
Cancer Lett. 2008 Sep 8;268(1):63-9. doi: 10.1016/j.canlet.2008.03.047. Epub 2008 May 12.
Cancer Lett. 2008.
PMID: 18468785
Free PMC article.
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