Hamilton AD - Search Results

1

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.

Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM. Falsetti SC, et al. Among authors: hamilton ad. Mol Cell Biol. 2007 Nov;27(22):8003-14. doi: 10.1128/MCB.00057-07. Epub 2007 Sep 17. Mol Cell Biol. 2007. PMID: 17875936 Free PMC article.

2

Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis.

Dan HC, Jiang K, Coppola D, Hamilton A, Nicosia SV, Sebti SM, Cheng JQ. Dan HC, et al. Oncogene. 2004 Jan 22;23(3):706-15. doi: 10.1038/sj.onc.1207171. Oncogene. 2004. PMID: 14737105

3

Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.

Kazi A, Carie A, Blaskovich MA, Bucher C, Thai V, Moulder S, Peng H, Carrico D, Pusateri E, Pledger WJ, Berndt N, Hamilton A, Sebti SM. Kazi A, et al. Mol Cell Biol. 2009 Apr;29(8):2254-63. doi: 10.1128/MCB.01029-08. Epub 2009 Feb 9. Mol Cell Biol. 2009. PMID: 19204084 Free PMC article.

4

Targeting protein prenylation for cancer therapy.

Berndt N, Hamilton AD, Sebti SM. Berndt N, et al. Among authors: hamilton ad. Nat Rev Cancer. 2011 Oct 24;11(11):775-91. doi: 10.1038/nrc3151. Nat Rev Cancer. 2011. PMID: 22020205 Free PMC article.

5

Farnesyltransferase inhibitors as anticancer agents: current status.

Zhu K, Hamilton AD, Sebti SM. Zhu K, et al. Among authors: hamilton ad. Curr Opin Investig Drugs. 2003 Dec;4(12):1428-35. Curr Opin Investig Drugs. 2003. PMID: 14763128 Review.

6

p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

Adnane J, Bizouarn FA, Qian Y, Hamilton AD, Sebti SM. Adnane J, et al. Among authors: hamilton ad. Mol Cell Biol. 1998 Dec;18(12):6962-70. doi: 10.1128/MCB.18.12.6962. Mol Cell Biol. 1998. PMID: 9819384 Free PMC article.

7

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis.

Jiang K, Coppola D, Crespo NC, Nicosia SV, Hamilton AD, Sebti SM, Cheng JQ. Jiang K, et al. Among authors: hamilton ad. Mol Cell Biol. 2000 Jan;20(1):139-48. doi: 10.1128/MCB.20.1.139-148.2000. Mol Cell Biol. 2000. PMID: 10594016 Free PMC article.

8

Inhibition of Rho GTPases using protein geranylgeranyltransferase I inhibitors.

Sebti SM, Hamilton AD. Sebti SM, et al. Among authors: hamilton ad. Methods Enzymol. 2000;325:381-8. doi: 10.1016/s0076-6879(00)25459-1. Methods Enzymol. 2000. PMID: 11036620 No abstract available.

9

Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues.

Sebti SM, Hamilton AD. Sebti SM, et al. Among authors: hamilton ad. Expert Opin Investig Drugs. 2000 Dec;9(12):2767-82. doi: 10.1517/13543784.9.12.2767. Expert Opin Investig Drugs. 2000. PMID: 11093352 Review.

10

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies.

Sebti SM, Hamilton AD. Sebti SM, et al. Among authors: hamilton ad. Oncogene. 2000 Dec 27;19(56):6584-93. doi: 10.1038/sj.onc.1204146. Oncogene. 2000. PMID: 11426643 Review.

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