Sparrow JR - Search Results

1

SOD2 knockdown mouse model of early AMD.

Justilien V, Pang JJ, Renganathan K, Zhan X, Crabb JW, Kim SR, Sparrow JR, Hauswirth WW, Lewin AS. Justilien V, et al. Among authors: sparrow jr. Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4407-20. doi: 10.1167/iovs.07-0432. Invest Ophthalmol Vis Sci. 2007. PMID: 17898259 Free PMC article.

2

Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE.

Sparrow JR, Zhou J, Ben-Shabat S, Vollmer H, Itagaki Y, Nakanishi K. Sparrow JR, et al. Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1222-7. Invest Ophthalmol Vis Sci. 2002. PMID: 11923269

3

Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.

Kim SR, Fishkin N, Kong J, Nakanishi K, Allikmets R, Sparrow JR. Kim SR, et al. Among authors: sparrow jr. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11668-72. doi: 10.1073/pnas.0403499101. Epub 2004 Jul 26. Proc Natl Acad Sci U S A. 2004. PMID: 15277666 Free PMC article.

4

Photooxidation of A2-PE, a photoreceptor outer segment fluorophore, and protection by lutein and zeaxanthin.

Kim SR, Nakanishi K, Itagaki Y, Sparrow JR. Kim SR, et al. Among authors: sparrow jr. Exp Eye Res. 2006 May;82(5):828-39. doi: 10.1016/j.exer.2005.10.004. Epub 2005 Dec 20. Exp Eye Res. 2006. PMID: 16364293

5

Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation.

Maiti P, Kong J, Kim SR, Sparrow JR, Allikmets R, Rando RR. Maiti P, et al. Among authors: sparrow jr. Biochemistry. 2006 Jan 24;45(3):852-60. doi: 10.1021/bi0518545. Biochemistry. 2006. PMID: 16411761

6

Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium.

Zhou J, Jang YP, Kim SR, Sparrow JR. Zhou J, et al. Among authors: sparrow jr. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16182-7. doi: 10.1073/pnas.0604255103. Epub 2006 Oct 23. Proc Natl Acad Sci U S A. 2006. PMID: 17060630 Free PMC article.

7

Characterization of dihydro-A2PE: an intermediate in the A2E biosynthetic pathway.

Kim SR, He J, Yanase E, Jang YP, Berova N, Sparrow JR, Nakanishi K. Kim SR, et al. Among authors: sparrow jr. Biochemistry. 2007 Sep 4;46(35):10122-9. doi: 10.1021/bi7009635. Epub 2007 Aug 8. Biochemistry. 2007. PMID: 17685561 Free PMC article.

8

The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model.

Kim SR, Jang YP, Jockusch S, Fishkin NE, Turro NJ, Sparrow JR. Kim SR, et al. Among authors: sparrow jr. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19273-8. doi: 10.1073/pnas.0708714104. Epub 2007 Nov 28. Proc Natl Acad Sci U S A. 2007. PMID: 18048333 Free PMC article.

9

A2E, a pigment of RPE lipofuscin, is generated from the precursor, A2PE by a lysosomal enzyme activity.

Sparrow JR, Kim SR, Cuervo AM, Bandhyopadhyayand U. Sparrow JR, et al. Adv Exp Med Biol. 2008;613:393-8. doi: 10.1007/978-0-387-74904-4_46. Adv Exp Med Biol. 2008. PMID: 18188969 No abstract available.

10

Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice.

Allocca M, Doria M, Petrillo M, Colella P, Garcia-Hoyos M, Gibbs D, Kim SR, Maguire A, Rex TS, Di Vicino U, Cutillo L, Sparrow JR, Williams DS, Bennett J, Auricchio A. Allocca M, et al. Among authors: sparrow jr. J Clin Invest. 2008 May;118(5):1955-64. doi: 10.1172/JCI34316. J Clin Invest. 2008. PMID: 18414684 Free PMC article.

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