Mutlib AE - Search Results

1

Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites.

Kostrubsky SE, Strom SC, Ellis E, Nelson SD, Mutlib AE. Kostrubsky SE, et al. Among authors: mutlib ae. Chem Res Toxicol. 2007 Oct;20(10):1503-12. doi: 10.1021/tx7001542. Epub 2007 Sep 28. Chem Res Toxicol. 2007. PMID: 17900172

2

Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes.

Kostrubsky SE, Sinclair JF, Strom SC, Wood S, Urda E, Stolz DB, Wen YH, Kulkarni S, Mutlib A. Kostrubsky SE, et al. Toxicol Sci. 2005 Sep;87(1):146-55. doi: 10.1093/toxsci/kfi211. Epub 2005 Jun 2. Toxicol Sci. 2005. PMID: 15933229

3

Identification of potential genomic biomarkers of hepatotoxicity caused by reactive metabolites of N-methylformamide: Application of stable isotope labeled compounds in toxicogenomic studies.

Mutlib A, Jiang P, Atherton J, Obert L, Kostrubsky S, Madore S, Nelson S. Mutlib A, et al. Chem Res Toxicol. 2006 Oct;19(10):1270-83. doi: 10.1021/tx060093j. Chem Res Toxicol. 2006. PMID: 17040096

4

Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity.

Mutlib AE, Goosen TC, Bauman JN, Williams JA, Kulkarni S, Kostrubsky S. Mutlib AE, et al. Chem Res Toxicol. 2006 May;19(5):701-9. doi: 10.1021/tx050317i. Chem Res Toxicol. 2006. PMID: 16696573

5

Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone.

Kostrubsky SE, Strom SC, Kalgutkar AS, Kulkarni S, Atherton J, Mireles R, Feng B, Kubik R, Hanson J, Urda E, Mutlib AE. Kostrubsky SE, et al. Among authors: mutlib ae. Toxicol Sci. 2006 Apr;90(2):451-9. doi: 10.1093/toxsci/kfj095. Epub 2006 Jan 12. Toxicol Sci. 2006. PMID: 16410371

6

Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: characterization of thioether conjugates by liquid chromatography/mass spectrometry and high field nuclear magnetic resonance spectroscopy.

Chen H, Grover S, Yu L, Walker G, Mutlib A. Chen H, et al. Chem Res Toxicol. 2010 Jan;23(1):159-70. doi: 10.1021/tx9003243. Chem Res Toxicol. 2010. PMID: 19961160

7

Bioactivation of a dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide) scaffold to a putative p-chlorophenyl isocyanate in rat liver microsomes and in vivo in rats.

Chen H, Zhang Y, Edmunds J, Bigge C, Mutlib A. Chen H, et al. Chem Res Toxicol. 2008 May;21(5):1095-106. doi: 10.1021/tx7004019. Epub 2008 Apr 5. Chem Res Toxicol. 2008. PMID: 18393453

8

Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes.

Chen H, Zientek M, Jalaie M, Zhang Y, Bigge C, Mutlib A. Chen H, et al. Chem Res Toxicol. 2009 Sep;22(9):1603-12. doi: 10.1021/tx900167y. Chem Res Toxicol. 2009. PMID: 19697924

9

Metabolism-dependent mutagenicity of a compound containing a piperazinyl indazole motif: Role of a novel p450-mediated metabolic reaction involving a putative oxaziridine intermediate.

Chen H, Murray J, Kornberg B, Dethloff L, Rock D, Nikam S, Mutlib AE. Chen H, et al. Among authors: mutlib ae. Chem Res Toxicol. 2006 Oct;19(10):1341-50. doi: 10.1021/tx050354+. Chem Res Toxicol. 2006. PMID: 17040103

10

A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.

Kalgutkar AS, Driscoll J, Zhao SX, Walker GS, Shepard RM, Soglia JR, Atherton J, Yu L, Mutlib AE, Munchhof MJ, Reiter LA, Jones CS, Doty JL, Trevena KA, Shaffer CL, Ripp SL. Kalgutkar AS, et al. Among authors: mutlib ae. Chem Res Toxicol. 2007 Dec;20(12):1954-65. doi: 10.1021/tx700270r. Epub 2007 Oct 13. Chem Res Toxicol. 2007. PMID: 17935300

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