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Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects.
Chiovitti K, Corsaro A, Thellung S, Villa V, Paludi D, D'Arrigo C, Russo C, Perico A, Ianieri A, Di Cola D, Vergara A, Aceto A, Florio T. Chiovitti K, et al. Among authors: aceto a. J Neurochem. 2007 Dec;103(6):2597-609. doi: 10.1111/j.1471-4159.2007.04965.x. Epub 2007 Oct 18. J Neurochem. 2007. PMID: 17944873 Free article.
Calcium binding promotes prion protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure.
Sorrentino S, Bucciarelli T, Corsaro A, Tosatto A, Thellung S, Villa V, Schininà ME, Maras B, Galeno R, Scotti L, Creati F, Marrone A, Re N, Aceto A, Florio T, Mazzanti M. Sorrentino S, et al. Among authors: aceto a. PLoS One. 2012;7(7):e38314. doi: 10.1371/journal.pone.0038314. Epub 2012 Jul 11. PLoS One. 2012. PMID: 22811758 Free PMC article.
114 results