Walkinshaw MD - Search Results

1

Structure-based discovery of a family of synthetic cyclophilin inhibitors showing a cyclosporin-A phenotype in Caenorhabditis elegans.

Yang Y, Moir E, Kontopidis G, Taylor P, Wear MA, Malone K, Dunsmore CJ, Page AP, Turner NJ, Walkinshaw MD. Yang Y, et al. Among authors: walkinshaw md. Biochem Biophys Res Commun. 2007 Nov 30;363(4):1013-9. doi: 10.1016/j.bbrc.2007.09.079. Epub 2007 Oct 1. Biochem Biophys Res Commun. 2007. PMID: 17927958

2

Structural and biological characterisation of the gut-associated cyclophilin B isoforms from Caenorhabditis elegans.

Picken NC, Eschenlauer S, Taylor P, Page AP, Walkinshaw MD. Picken NC, et al. Among authors: walkinshaw md. J Mol Biol. 2002 Sep 6;322(1):15-25. doi: 10.1016/s0022-2836(02)00712-x. J Mol Biol. 2002. PMID: 12215411

3

Cloning, expression and characterisation of FKB-6, the sole large TPR-containing immunophilin from C. elegans.

Richardson JM, Dornan J, Opamawutthikul M, Bruce S, Page AP, Walkinshaw MD. Richardson JM, et al. Among authors: walkinshaw md. Biochem Biophys Res Commun. 2007 Aug 31;360(3):566-72. doi: 10.1016/j.bbrc.2007.06.080. Epub 2007 Jun 26. Biochem Biophys Res Commun. 2007. PMID: 17610845

4

Cloning, purification and characterization of the Caenorhabditis elegans small glutamine-rich tetratricopeptide repeat-containing protein.

Worrall LJ, Wear MA, Page AP, Walkinshaw MD. Worrall LJ, et al. Among authors: walkinshaw md. Biochim Biophys Acta. 2008 Mar;1784(3):496-503. doi: 10.1016/j.bbapap.2007.12.003. Epub 2007 Dec 15. Biochim Biophys Acta. 2008. PMID: 18187053

5

Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans.

Dunsmore CJ, Malone KJ, Bailey KR, Wear MA, Florance H, Shirran S, Barran PE, Page AP, Walkinshaw MD, Turner NJ. Dunsmore CJ, et al. Among authors: walkinshaw md. Chembiochem. 2011 Mar 21;12(5):802-10. doi: 10.1002/cbic.201000413. Epub 2011 Feb 17. Chembiochem. 2011. PMID: 21337480

6

A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

Morgan HP, Walsh MJ, Blackburn EA, Wear MA, Boxer MB, Shen M, Veith H, McNae IW, Nowicki MW, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD. Morgan HP, et al. Among authors: walkinshaw md. Biochem J. 2012 Nov 15;448(1):67-72. doi: 10.1042/BJ20121014. Biochem J. 2012. PMID: 22906073 Free PMC article.

7

A surface plasmon resonance-based assay for small molecule inhibitors of human cyclophilin A.

Wear MA, Patterson A, Malone K, Dunsmore C, Turner NJ, Walkinshaw MD. Wear MA, et al. Among authors: walkinshaw md. Anal Biochem. 2005 Oct 15;345(2):214-26. doi: 10.1016/j.ab.2005.06.037. Anal Biochem. 2005. PMID: 16102717 Free PMC article.

8

Selective chemical intervention in the proteome of Caenorhabditis elegans.

Husi H, McAllister F, Angelopoulos N, Butler VJ, Bailey KR, Malone K, Mackay L, Taylor P, Page AP, Turner NJ, Barran PE, Walkinshaw M. Husi H, et al. J Proteome Res. 2010 Nov 5;9(11):6060-70. doi: 10.1021/pr100427c. Epub 2010 Sep 22. J Proteome Res. 2010. PMID: 20804218

9

Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop.

Wu SY, McNae I, Kontopidis G, McClue SJ, McInnes C, Stewart KJ, Wang S, Zheleva DI, Marriage H, Lane DP, Taylor P, Fischer PM, Walkinshaw MD. Wu SY, et al. Among authors: walkinshaw md. Structure. 2003 Apr;11(4):399-410. doi: 10.1016/s0969-2126(03)00060-1. Structure. 2003. PMID: 12679018 Free article.

10

Structures of immunophilins and their ligand complexes.

Dornan J, Taylor P, Walkinshaw MD. Dornan J, et al. Among authors: walkinshaw md. Curr Top Med Chem. 2003;3(12):1392-409. doi: 10.2174/1568026033451899. Curr Top Med Chem. 2003. PMID: 12871171 Review.

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