Li G - Search Results

1

Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors.

Li G, Tao ZF, Tong Y, Przytulinska MK, Kovar P, Merta P, Chen Z, Zhang H, Sowin T, Rosenberg SH, Lin NH. Li G, et al. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6499-504. doi: 10.1016/j.bmcl.2007.09.088. Epub 2007 Sep 29. Bioorg Med Chem Lett. 2007. PMID: 17931867

2

1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.

Wang GT, Li G, Mantei RA, Chen Z, Kovar P, Gu W, Xiao Z, Zhang H, Sham HL, Sowin T, Rosenberg SH, Lin NH. Wang GT, et al. Among authors: li g. J Med Chem. 2005 May 5;48(9):3118-21. doi: 10.1021/jm048989d. J Med Chem. 2005. PMID: 15857116

3

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.

Li G, Hasvold LA, Tao ZF, Wang GT, Gwaltney SL 2nd, Patel J, Kovar P, Credo RB, Chen Z, Zhang H, Park C, Sham HL, Sowin T, Rosenberg SH, Lin NH. Li G, et al. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2293-8. doi: 10.1016/j.bmcl.2006.01.028. Epub 2006 Jan 30. Bioorg Med Chem Lett. 2006. PMID: 16446090

4

Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics.

Chen Z, Xiao Z, Gu WZ, Xue J, Bui MH, Kovar P, Li G, Wang G, Tao ZF, Tong Y, Lin NH, Sham HL, Wang JY, Sowin TJ, Rosenberg SH, Zhang H. Chen Z, et al. Among authors: li g. Int J Cancer. 2006 Dec 15;119(12):2784-94. doi: 10.1002/ijc.22198. Int J Cancer. 2006. PMID: 17019715

5

Synthesis and biological evaluation of 4'-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors.

Tao ZF, Li G, Tong Y, Chen Z, Merta P, Kovar P, Zhang H, Rosenberg SH, Sham HL, Sowin TJ, Lin NH. Tao ZF, et al. Among authors: li g. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4308-15. doi: 10.1016/j.bmcl.2007.05.027. Epub 2007 May 16. Bioorg Med Chem Lett. 2007. PMID: 17544271

6

Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors.

Wang L, Sullivan GM, Hexamer LA, Hasvold LA, Thalji R, Przytulinska M, Tao ZF, Li G, Chen Z, Xiao Z, Gu WZ, Xue J, Bui MH, Merta P, Kovar P, Bouska JJ, Zhang H, Park C, Stewart KD, Sham HL, Sowin TJ, Rosenberg SH, Lin NH. Wang L, et al. Among authors: li g. J Med Chem. 2007 Aug 23;50(17):4162-76. doi: 10.1021/jm070105d. Epub 2007 Jul 21. J Med Chem. 2007. PMID: 17658776

7

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: improving oral biovailability.

Tong Y, Przytulinska M, Tao ZF, Bouska J, Stewart KD, Park C, Li G, Claiborne A, Kovar P, Chen Z, Merta PJ, Bui MH, Olson A, Osterling D, Zhang H, Sham HL, Rosenberg SH, Sowin TJ, Lin NH. Tong Y, et al. Among authors: li g. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5665-70. doi: 10.1016/j.bmcl.2007.07.069. Epub 2007 Aug 21. Bioorg Med Chem Lett. 2007. PMID: 17768051

8

Discovery of 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2'-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors.

Tao ZF, Li G, Tong Y, Stewart KD, Chen Z, Bui MH, Merta P, Park C, Kovar P, Zhang H, Sham HL, Rosenberg SH, Sowin TJ, Lin NH. Tao ZF, et al. Among authors: li g. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5944-51. doi: 10.1016/j.bmcl.2007.07.102. Epub 2007 Aug 25. Bioorg Med Chem Lett. 2007. PMID: 17827013

9

Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors.

Xiao Z, Xue J, Gu WZ, Bui M, Li G, Tao ZF, Lin NH, Sowin TJ, Zhang H. Xiao Z, et al. Among authors: li g. Biomarkers. 2008 Sep;13(6):579-96. doi: 10.1080/13547500802063240. Biomarkers. 2008. PMID: 18671143

10

Optimization and metabolic stabilization of a class of nonsteroidal glucocorticoid modulators.

Link JT, Sorensen BK, Patel J, Arendsen D, Li G, Swanson S, Nguyen B, Emery M, Grynfarb M, Goos-Nilsson A. Link JT, et al. Among authors: li g. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4169-72. doi: 10.1016/j.bmcl.2004.06.023. Bioorg Med Chem Lett. 2004. PMID: 15261264

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