Kiakos K - Search Results

1

DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.

Kiakos K, Sato A, Asao T, McHugh PJ, Lee M, Hartley JA. Kiakos K, et al. Mol Cancer Ther. 2007 Oct;6(10):2708-18. doi: 10.1158/1535-7163.MCT-07-0294. Mol Cancer Ther. 2007. PMID: 17938264

2

Saccharomyces cerevisiae RAD5 influences the excision repair of DNA minor groove adducts.

Kiakos K, Howard TT, Lee M, Hartley JA, McHugh PJ. Kiakos K, et al. J Biol Chem. 2002 Nov 15;277(46):44576-81. doi: 10.1074/jbc.M208169200. Epub 2002 Sep 10. J Biol Chem. 2002. PMID: 12226100 Free article.

3

A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.

Kupchinsky S, Centioni S, Howard T, Trzupek J, Roller S, Carnahan V, Townes H, Purnell B, Price C, Handl H, Summerville K, Johnson K, Toth J, Hudson S, Kiakos K, Hartley JA, Lee M. Kupchinsky S, et al. Among authors: kiakos k. Bioorg Med Chem. 2004 Dec 1;12(23):6221-36. doi: 10.1016/j.bmc.2004.08.051. Bioorg Med Chem. 2004. PMID: 15519165

4

Design, synthesis, and biological evaluation of achiral analogs of duocarmycin SA.

Daniell K, Stewart M, Madsen E, Le M, Handl H, Brooks N, Kiakos K, Hartley JA, Lee M. Daniell K, et al. Among authors: kiakos k. Bioorg Med Chem Lett. 2005 Jan 3;15(1):177-80. doi: 10.1016/j.bmcl.2004.10.021. Bioorg Med Chem Lett. 2005. PMID: 15582435

5

A novel class of in vivo active anticancer agents: achiral seco-amino- and seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) analogues of the duocarmycins and CC-1065.

Sato A, McNulty L, Cox K, Kim S, Scott A, Daniell K, Summerville K, Price C, Hudson S, Kiakos K, Hartley JA, Asao T, Lee M. Sato A, et al. Among authors: kiakos k. J Med Chem. 2005 Jun 2;48(11):3903-18. doi: 10.1021/jm050179u. J Med Chem. 2005. PMID: 15916443

6

A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.

Toth JL, Trzupek JD, Flores LV, Kiakos K, Hartley JA, Pennington WT, Lee M. Toth JL, et al. Among authors: kiakos k. Med Chem. 2005 Jan;1(1):13-9. doi: 10.2174/1573406053402523. Med Chem. 2005. PMID: 16789881

7

DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).

Purnell B, Sato A, O'kelley A, Price C, Summerville K, Hudson S, O'hare C, Kiakos K, Asao T, Lee M, Hartley JA. Purnell B, et al. Among authors: kiakos k. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5677-81. doi: 10.1016/j.bmcl.2006.08.005. Epub 2006 Aug 21. Bioorg Med Chem Lett. 2006. PMID: 16919946

8

Measurement of DNA interstrand crosslinking in naked DNA using gel-based methods.

Kiakos K, Hartley JM, Hartley JA. Kiakos K, et al. Methods Mol Biol. 2010;613:283-302. doi: 10.1007/978-1-60327-418-0_18. Methods Mol Biol. 2010. PMID: 19997891

9

A novel achiral seco-cyclopropylpyrido[e]indolone (CPyI) analog of CC-1065 and the duocarmycins: synthesis, DNA interactions, in vivo anticancer and anti-parasitic evaluation.

Chavda S, Babu B, Yanow SK, Jardim A, Spithill TW, Kiakos K, Kluza J, Hartley JA, Lee M. Chavda S, et al. Among authors: kiakos k. Bioorg Med Chem. 2010 Jul 15;18(14):5016-24. doi: 10.1016/j.bmc.2010.05.078. Epub 2010 Jun 4. Bioorg Med Chem. 2010. PMID: 20579889

10

Evidence for different mechanisms of 'unhooking' for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples.

Spanswick VJ, Lowe HL, Newton C, Bingham JP, Bagnobianchi A, Kiakos K, Craddock C, Ledermann JA, Hochhauser D, Hartley JA. Spanswick VJ, et al. Among authors: kiakos k. BMC Cancer. 2012 Sep 28;12:436. doi: 10.1186/1471-2407-12-436. BMC Cancer. 2012. PMID: 23020514 Free PMC article.

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