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PPRX-1701, a nanoparticle formulation of 6'-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models.
Zdioruk M, Jimenez-Macias JL, Nowicki MO, Manz KE, Pennell KD, Koch MS, Finkelberg T, Wu B, Boucher P, Takeda Y, Li W, Piranlioglu R, Ling AL, Chiocca EA, Lawler SE. Zdioruk M, et al. Among authors: koch ms. Cell Rep Med. 2023 May 16;4(5):101019. doi: 10.1016/j.xcrm.2023.101019. Epub 2023 Apr 14. Cell Rep Med. 2023. PMID: 37060903 Free PMC article.
Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma.
Koch MS, Zdioruk M, Nowicki MO, Griffith AM, Aguilar-Cordova E, Aguilar LK, Guzik BW, Barone F, Tak PP, Schregel K, Hoetker MS, Lederer JA, Chiocca EA, Tabatabai G, Lawler SE. Koch MS, et al. Mol Ther Oncolytics. 2022 Jul 31;26:275-288. doi: 10.1016/j.omto.2022.07.009. eCollection 2022 Sep 15. Mol Ther Oncolytics. 2022. PMID: 36032633 Free PMC article.
Experimental glioma with high bHLH expression harbor increased replicative stress and are sensitive toward ATR inhibition.
Koch MS, Czemmel S, Lennartz F, Beyeler S, Rajaraman S, Przystal JM, Govindarajan P, Canjuga D, Neumann M, Rizzu P, Zwirner S, Hoetker MS, Zender L, Walter B, Tatagiba M, Raineteau O, Heutink P, Nahnsen S, Tabatabai G. Koch MS, et al. Neurooncol Adv. 2020 Sep 10;2(1):vdaa115. doi: 10.1093/noajnl/vdaa115. eCollection 2020 Jan-Dec. Neurooncol Adv. 2020. PMID: 33134924 Free PMC article.
37 results