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beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
Baillie GS, Sood A, McPhee I, Gall I, Perry SJ, Lefkowitz RJ, Houslay MD. Baillie GS, et al. Among authors: houslay md. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):940-5. doi: 10.1073/pnas.262787199. Epub 2003 Jan 27. Proc Natl Acad Sci U S A. 2003. Retraction in: Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2205198119. doi: 10.1073/pnas.2205198119 PMID: 12552097 Free PMC article. Retracted.
In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.
McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD. McCahill A, et al. Among authors: houslay md. Cell Signal. 2005 Sep;17(9):1158-73. doi: 10.1016/j.cellsig.2005.04.003. Cell Signal. 2005. PMID: 15905070
RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.
Lynch MJ, Baillie GS, Mohamed A, Li X, Maisonneuve C, Klussmann E, van Heeke G, Houslay MD. Lynch MJ, et al. Among authors: houslay md. J Biol Chem. 2005 Sep 30;280(39):33178-89. doi: 10.1074/jbc.M414316200. Epub 2005 Jul 19. J Biol Chem. 2005. PMID: 16030021 Free article.
413 results