Koch U - Search Results

1

Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.

Lahm A, Paolini C, Pallaoro M, Nardi MC, Jones P, Neddermann P, Sambucini S, Bottomley MJ, Lo Surdo P, Carfí A, Koch U, De Francesco R, Steinkühler C, Gallinari P. Lahm A, et al. Among authors: koch u. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17335-40. doi: 10.1073/pnas.0706487104. Epub 2007 Oct 23. Proc Natl Acad Sci U S A. 2007. PMID: 17956988 Free PMC article.

2

A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand.

Gallinari P, Lahm A, Koch U, Paolini C, Nardi MC, Roscilli G, Kinzel O, Fattori D, Muraglia E, Toniatti C, Cortese R, De Francesco R, Ciliberto G. Gallinari P, et al. Among authors: koch u. Chem Biol. 2005 Aug;12(8):883-93. doi: 10.1016/j.chembiol.2005.05.018. Chem Biol. 2005. PMID: 16125100 Free article.

3

A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies.

Kinzel O, Fattori D, Muraglia E, Gallinari P, Nardi MC, Paolini C, Roscilli G, Toniatti C, Gonzalez Paz O, Laufer R, Lahm A, Tramontano A, Cortese R, De Francesco R, Ciliberto G, Koch U. Kinzel O, et al. Among authors: koch u. J Med Chem. 2006 Sep 7;49(18):5404-7. doi: 10.1021/jm060516e. J Med Chem. 2006. PMID: 16942012

4

Product inhibition of the hepatitis C virus NS3 protease.

Steinkühler C, Biasiol G, Brunetti M, Urbani A, Koch U, Cortese R, Pessi A, De Francesco R. Steinkühler C, et al. Among authors: koch u. Biochemistry. 1998 Jun 23;37(25):8899-905. doi: 10.1021/bi980313v. Biochemistry. 1998. PMID: 9636031

5

Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies.

Cicero DO, Barbato G, Koch U, Ingallinella P, Bianchi E, Nardi MC, Steinkühler C, Cortese R, Matassa V, De Francesco R, Pessi A, Bazzo R. Cicero DO, et al. Among authors: koch u. J Mol Biol. 1999 Jun 4;289(2):385-96. doi: 10.1006/jmbi.1999.2746. J Mol Biol. 1999. PMID: 10366512

6

Role of charged residues in the catalytic mechanism of hepatitis C virus NS3 protease: electrostatic precollision guidance and transition-state stabilization.

Koch U, Biasiol G, Brunetti M, Fattori D, Pallaoro M, Steinkühler C. Koch U, et al. Biochemistry. 2001 Jan 23;40(3):631-40. doi: 10.1021/bi002160t. Biochemistry. 2001. PMID: 11170379

7

Measurement of homonuclear three-bond J(H(N)Halpha) coupling constants in unlabeled peptides complexed with labeled proteins: application to a decapeptide inhibitor bound to the proteinase domain of the NS3 protein of hepatitis C virus (HCV).

Cicero DO, Barbato G, Koch U, Ingallinella P, Bianchi E, Sambucini S, Neddermann P, De Francesco R, Pessi A, Bazzo R. Cicero DO, et al. Among authors: koch u. J Biomol NMR. 2001 May;20(1):23-9. doi: 10.1023/a:1011281527761. J Biomol NMR. 2001. PMID: 11430752

8

Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site.

Di Marco S, Volpari C, Tomei L, Altamura S, Harper S, Narjes F, Koch U, Rowley M, De Francesco R, Migliaccio G, Carfí A. Di Marco S, et al. Among authors: koch u. J Biol Chem. 2005 Aug 19;280(33):29765-70. doi: 10.1074/jbc.M505423200. Epub 2005 Jun 13. J Biol Chem. 2005. PMID: 15955819 Free article.

9

Hepatitis C virus protease inhibitors: current progress and future challenges.

Steinkühler C, Koch U, Narjes F, Matassa VG. Steinkühler C, et al. Among authors: koch u. Curr Med Chem. 2001 Jul;8(8):919-932. doi: 10.2174/0929867013372814. Curr Med Chem. 2001. PMID: 11375758 Review.

10

Recent developments in the discovery of hepatitis C virus serine protease inhibitors--towards a new class of antiviral agents?

Narjes F, Koch U, Steinkühler C. Narjes F, et al. Among authors: koch u. Expert Opin Investig Drugs. 2003 Feb;12(2):153-63. doi: 10.1517/13543784.12.2.153. Expert Opin Investig Drugs. 2003. PMID: 12556211 Review.

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