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Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1.
Moeschel K, Beck A, Weigert C, Lammers R, Kalbacher H, Voelter W, Schleicher ED, Häring HU, Lehmann R. Moeschel K, et al. Among authors: beck a. J Biol Chem. 2004 Jun 11;279(24):25157-63. doi: 10.1074/jbc.M402477200. Epub 2004 Apr 5. J Biol Chem. 2004. PMID: 15069075 Free article.
The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal.
Weigert C, Hennige AM, Brischmann T, Beck A, Moeschel K, Schaüble M, Brodbeck K, Häring HU, Schleicher ED, Lehmann R. Weigert C, et al. Among authors: beck a. J Biol Chem. 2005 Nov 11;280(45):37393-9. doi: 10.1074/jbc.M506134200. Epub 2005 Aug 29. J Biol Chem. 2005. PMID: 16129678 Free article.
3,678 results