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219,833 results

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Page 1
N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors.
Vaisburg A, Paquin I, Bernstein N, Frechette S, Gaudette F, Leit S, Moradei O, Raeppel S, Zhou N, Bouchain G, Woo SH, Jin Z, Gillespie J, Wang J, Fournel M, Yan PT, Trachy-Bourget MC, Robert MF, Lu A, Yuk J, Rahil J, Macleod AR, Besterman JM, Li Z, Delorme D. Vaisburg A, et al. Among authors: wang j. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6729-33. doi: 10.1016/j.bmcl.2007.10.050. Epub 2007 Oct 18. Bioorg Med Chem Lett. 2007. PMID: 17977726
MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo.
Fournel M, Bonfils C, Hou Y, Yan PT, Trachy-Bourget MC, Kalita A, Liu J, Lu AH, Zhou NZ, Robert MF, Gillespie J, Wang JJ, Ste-Croix H, Rahil J, Lefebvre S, Moradei O, Delorme D, Macleod AR, Besterman JM, Li Z. Fournel M, et al. Among authors: wang jj. Mol Cancer Ther. 2008 Apr;7(4):759-68. doi: 10.1158/1535-7163.MCT-07-2026. Mol Cancer Ther. 2008. PMID: 18413790
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.
Therrien E, Larouche G, Nguyen N, Rahil J, Lemieux AM, Li Z, Fournel M, Yan TP, Landry AJ, Lefebvre S, Wang JJ, MacBeth K, Heise C, Nguyen A, Besterman JM, Déziel R, Wahhab A. Therrien E, et al. Among authors: wang jj. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2514-8. doi: 10.1016/j.bmcl.2015.04.068. Epub 2015 Apr 28. Bioorg Med Chem Lett. 2015. PMID: 25971769
(2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors.
Vaisburg A, Bernstein N, Frechette S, Allan M, Abou-Khalil E, Leit S, Moradei O, Bouchain G, Wang J, Woo SH, Fournel M, Yan PT, Trachy-Bourget MC, Kalita A, Beaulieu C, Li Z, MacLeod AR, Besterman JM, Delorme D. Vaisburg A, et al. Among authors: wang j. Bioorg Med Chem Lett. 2004 Jan 5;14(1):283-7. doi: 10.1016/j.bmcl.2003.08.083. Bioorg Med Chem Lett. 2004. PMID: 14684344
Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases.
Claridge S, Raeppel F, Granger MC, Bernstein N, Saavedra O, Zhan L, Llewellyn D, Wahhab A, Deziel R, Rahil J, Beaulieu N, Nguyen H, Dupont I, Barsalou A, Beaulieu C, Chute I, Gravel S, Robert MF, Lefebvre S, Dubay M, Pascal R, Gillespie J, Jin Z, Wang J, Besterman JM, MacLeod AR, Vaisburg A. Claridge S, et al. Among authors: wang j. Bioorg Med Chem Lett. 2008 May 1;18(9):2793-8. doi: 10.1016/j.bmcl.2008.04.009. Epub 2008 Apr 9. Bioorg Med Chem Lett. 2008. PMID: 18434145
Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
Zhou N, Moradei O, Raeppel S, Leit S, Frechette S, Gaudette F, Paquin I, Bernstein N, Bouchain G, Vaisburg A, Jin Z, Gillespie J, Wang J, Fournel M, Yan PT, Trachy-Bourget MC, Kalita A, Lu A, Rahil J, MacLeod AR, Li Z, Besterman JM, Delorme D. Zhou N, et al. Among authors: wang j. J Med Chem. 2008 Jul 24;51(14):4072-5. doi: 10.1021/jm800251w. Epub 2008 Jun 21. J Med Chem. 2008. PMID: 18570366
SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
Raeppel S, Zhou N, Gaudette F, Leit S, Paquin I, Larouche G, Moradei O, Fréchette S, Isakovic L, Delorme D, Fournel M, Kalita A, Lu A, Trachy-Bourget MC, Yan PT, Liu J, Rahil J, Wang J, Besterman JM, Murakami K, Li Z, Vaisburg A. Raeppel S, et al. Among authors: wang j. Bioorg Med Chem Lett. 2009 Feb 1;19(3):644-9. doi: 10.1016/j.bmcl.2008.12.048. Epub 2008 Dec 24. Bioorg Med Chem Lett. 2009. PMID: 19114304
N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
Raeppel S, Claridge S, Saavedra O, Gaudette F, Zhan L, Mannion M, Zhou N, Raeppel F, Granger MC, Isakovic L, Déziel R, Nguyen H, Beaulieu N, Beaulieu C, Dupont I, Robert MF, Lefebvre S, Dubay M, Rahil J, Wang J, Ste-Croix H, Robert Macleod A, Besterman J, Vaisburg A. Raeppel S, et al. Among authors: wang j. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1323-8. doi: 10.1016/j.bmcl.2009.01.068. Epub 2009 Jan 27. Bioorg Med Chem Lett. 2009. PMID: 19211249
Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors.
Manku S, Allan M, Nguyen N, Ajamian A, Rodrigue J, Therrien E, Wang J, Guo T, Rahil J, Petschner AJ, Nicolescu A, Lefebvre S, Li Z, Fournel M, Besterman JM, Déziel R, Wahhab A. Manku S, et al. Among authors: wang j. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1866-70. doi: 10.1016/j.bmcl.2009.02.075. Epub 2009 Feb 23. Bioorg Med Chem Lett. 2009. PMID: 19272776
219,833 results
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